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Finlay D, Teriete P, Vamos M, et al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017;6:587doi: 10.12688/f1000research.10625.1.
Finlay, D., Teriete, P., Vamos, M., Cosford, N. D. P., & Vuori, K. (2017). Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Research, 6587. https://doi.org/10.12688/f1000research.10625.1
Finlay, Darren, et al. "Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins." F1000Research vol. 6 (2017): 587. doi: https://doi.org/10.12688/f1000research.10625.1
Finlay D, Teriete P, Vamos M, Cosford NDP, Vuori K. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27;6:587. doi: 10.12688/f1000research.10625.1. eCollection 2017. PMID: 28529715; PMCID: PMC5414821.
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F1000Res. 2017 Apr 27;6:587. doi: 10.12688/f1000research.10625.1. eCollection 2017.

Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins.

F1000Research

Darren Finlay, Peter Teriete, Mitchell Vamos, Nicholas D P Cosford, Kristiina Vuori

Affiliations

  1. NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.

PMID: 28529715 PMCID: PMC5414821 DOI: 10.12688/f1000research.10625.1

Abstract

The heterogeneous group of diseases collectively termed cancer results not just from aberrant cellular proliferation but also from a lack of accompanying homeostatic cell death. Indeed, cancer cells regularly acquire resistance to programmed cell death, or apoptosis, which not only supports cancer progression but also leads to resistance to therapeutic agents. Thus, various approaches have been undertaken in order to induce apoptosis in tumor cells for therapeutic purposes. Here, we will focus our discussion on agents that directly affect the apoptotic machinery itself rather than on drugs that induce apoptosis in tumor cells indirectly, such as by DNA damage or kinase dependency inhibition. As the roles of the Bcl-2 family have been extensively studied and reviewed recently, we will focus in this review specifically on the inhibitor of apoptosis protein (IAP) family. IAPs are a disparate group of proteins that all contain a baculovirus IAP repeat domain, which is important for the inhibition of apoptosis in some, but not all, family members. We describe each of the family members with respect to their structural and functional similarities and differences and their respective roles in cancer. Finally, we also review the current state of IAPs as targets for anti-cancer therapeutics and discuss the current clinical state of IAP antagonists.

Keywords: IAPs; apoptosis; cancer; inhibitor of apoptosis proteins; tumours

Conflict of interest statement

Competing interests: No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were

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