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Jammalamadaka U, Tappa K, Weisman JA, et al. Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement. Nanotechnol Sci Appl. 2017;10:105-114doi: 10.2147/NSA.S131412.
Jammalamadaka, U., Tappa, K., Weisman, J. A., Nicholson, J. C., & Mills, D. K. (2017). Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement. Nanotechnology, science and applications, 10105-114. https://doi.org/10.2147/NSA.S131412
Jammalamadaka, Uday, et al. "Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement." Nanotechnology, science and applications vol. 10 (2017): 105-114. doi: https://doi.org/10.2147/NSA.S131412
Jammalamadaka U, Tappa K, Weisman JA, Nicholson JC, Mills DK. Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement. Nanotechnol Sci Appl. 2017 Jun 12;10:105-114. doi: 10.2147/NSA.S131412. eCollection 2017. PMID: 28652713; PMCID: PMC5476764.
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Nanotechnol Sci Appl. 2017 Jun 12;10:105-114. doi: 10.2147/NSA.S131412. eCollection 2017.

Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement.

Nanotechnology, science and applications

Uday Jammalamadaka, Karthik Tappa, Jeffery A Weisman, James Connor Nicholson, David K Mills

Affiliations

  1. Center for Biomedical Engineering and Rehabilitation Science.
  2. Nanosystems Engineering.
  3. The School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA.

PMID: 28652713 PMCID: PMC5476764 DOI: 10.2147/NSA.S131412

Abstract

Halloysite nanotubes (HNTs) were investigated as a platform for tunable nanoparticle composition and enhanced opacity in poly(methyl methacrylate) (PMMA) bone cement. Halloysite has been widely used to increase the mechanical properties of various polymer matrices, in stark contrast to other fillers such as barium sulfate that provide opacity but also decrease mechanical strength. The present work describes a dry deposition method for successively fabricating barium sulfate nanoparticles onto the exterior surface of HNTs. A sintering process was used to coat the HNTs in barium sulfate. Barium sulfate-coated HNTs were then added to PMMA bone cement and the samples were tested for mechanical strength and tailored opacity correlated with the fabrication ratio and the amount of barium sulfate-coated HNTs added. The potential cytotoxic effect of barium-coated HNTs in PMMA cement was also tested on osteosarcoma cells. Barium-coated HNTs were found to be completely cytocompatible, and cell proliferation was not inhibited after exposure to the barium-coated HNTs embedded in PMMA cement. We demonstrate a simple method for the creation of barium-coated nanoparticles that imparted improved contrast and material properties to native PMMA. An easy and efficient method for coating clay nanotubes offers the potential for enhanced imaging by radiologists or orthopedic surgeons.

Keywords: PMMA; barium; bone cement; halloysite; imaging; sintering

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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