Am J Geriatr Psychiatry. 1995 Winter;3(1):52-59. doi: 10.1097/00019442-199524310-00007. Epub 2012 Aug 08.

Negative Symptoms in Patients With Alzheimer's Disease.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Igor I Galynker, David M Roane, Christian R Miner, Todd E Feinberg, Patricia Watts

PMID: 28530958 DOI: 10.1097/00019442-199524310-00007

Abstract

This study applies the concept of "negative symptoms," previously used in schizophrenia, to dementia of the Alzheimer type (DAT) and examines the relationship of negative symptoms to cognitive deficits and depression. The negative symptom subscale of the Positive and Negative Symptom Scale (PANSS-N), the Hamilton Depression Scale (Ham-D), and the Mini-Mental State Examination (MMSE) were administered to 26 patients with DAT and to 13 normal control subjects. The mean PANSS-N score in DAT patients was significantly higher than in control subjects. DAT patients demonstrated significant correlation between negative symptoms and cognitive deficits. Ham-D scores did not significantly correlate with MMSE or PANSS-N scores. These results indicate that negative symptoms are prevalent in DAT and do not result from depression.

Copyright © 1995 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

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