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Anwar M, Ahmad S, Akhtar R, et al. Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis. Technol Cancer Res Treat. 2017;16(6):676-691doi: 10.1177/1533034617707598.
Anwar, M., Ahmad, S., Akhtar, R., Mahmood, A., & Mahmood, S. (2017). Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis. Technology in cancer research & treatment, 16(6), 676-691. https://doi.org/10.1177/1533034617707598
Anwar, Mumtaz, et al. "Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis." Technology in cancer research & treatment vol. 16,6 (2017): 676-691. doi: https://doi.org/10.1177/1533034617707598
Anwar M, Ahmad S, Akhtar R, Mahmood A, Mahmood S. Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis. Technol Cancer Res Treat. 2017 Dec;16(6):676-691. doi: 10.1177/1533034617707598. Epub 2017 May 22. PMID: 28532242; PMCID: PMC5762044.
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Technol Cancer Res Treat. 2017 Dec;16(6):676-691. doi: 10.1177/1533034617707598. Epub 2017 May 22.

Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis.

Technology in cancer research & treatment

Mumtaz Anwar, Shabeer Ahmad, Reyhan Akhtar, Akhtar Mahmood, Safrun Mahmood

Affiliations

  1. Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  2. Department of Biochemistry, Panjab University, Chandigarh, India.

PMID: 28532242 PMCID: PMC5762044 DOI: 10.1177/1533034617707598

Abstract

Radiation enteritis is one of the most feared complications of abdominal and pelvic regions. Thus, radiation to abdominal or pelvic malignancies unavoidably injures the intestine. Because of rapid cell turnover, the intestine is highly sensitive to radiation injury, which is the limiting factor in the permissible dosage of irradiation. Bowel injuries such as fistulas, strictures, and chronic malabsorption are potentially life-threatening complications and have an impact on patient quality of life. The incidence of radiation enteritis is increasing because of the current trend of combined chemotherapy and radiation. The consequences of radiation damage to the intestine may result in considerable morbidity and even mortality. The observed effects of ionizing radiation are mediated mainly by oxygen-free radicals that are generated by its action on water and are involved in several steps of signal transduction cascade, leading to apoptosis. The oxyradicals also induce DNA strand breaks and protein oxidation. An important line of defense against free radical damage is the presence of antioxidants. Therefore, administration of antioxidants may ameliorate the radiation-induced damage to the intestine.

Keywords: DNA damage; apoptosis; brush border enzymes; expression; radiation-induced enteritis

References

  1. J Biol Chem. 2013 Jan 11;288(2):770-7 - PubMed
  2. Ther Adv Chronic Dis. 2014 Jan;5(1):15-29 - PubMed
  3. Ultraschall Med. 1984 Dec;5(6):281-6 - PubMed
  4. Radiother Oncol. 1994 Jul;32(1):29-36 - PubMed
  5. Breast Cancer Res Treat. 2002 Nov;76(2):137-43 - PubMed
  6. Antioxid Redox Signal. 2014 Mar 20;20(9):1436-46 - PubMed
  7. Bull Exp Biol Med. 2017 Feb;162(4):466-469 - PubMed
  8. Biochim Biophys Acta. 1998 Aug 10;1366(1-2):127-37 - PubMed
  9. Radiat Res. 1997 Sep;148(3):248-53 - PubMed
  10. Gynecol Oncol. 1980 Dec;10(3):290-7 - PubMed
  11. N Engl J Med. 1999 Jun 3;340(22):1733-9 - PubMed
  12. Curr Drug Targets. 2010 Nov;11(11):1366-74 - PubMed
  13. Radiother Oncol. 1997 Jul;44(1):1-7 - PubMed
  14. Br J Cancer Suppl. 1987 Jun;8:24-31 - PubMed
  15. Cardiovasc Res. 2007 May 1;74(2):184-95 - PubMed
  16. J R Soc Med. 1986 Jul;79(7):387-90 - PubMed
  17. J Clin Invest. 1966 Feb;45(2):194-204 - PubMed
  18. Antioxid Redox Signal. 2013 Sep 20;19(9):1036-44 - PubMed
  19. Cell Tissue Kinet. 1982 Jul;15(4):351-70 - PubMed
  20. Exp Cell Res. 2012 Jul 1;318(11):1269-77 - PubMed
  21. Science. 2001 Jul 13;293(5528):293-7 - PubMed
  22. Br J Cancer. 1998 Oct;78(8):993-1003 - PubMed
  23. J Mol Cell Cardiol. 2016 Sep;98:18-27 - PubMed
  24. Curr Opin Cell Biol. 2001 Dec;13(6):738-47 - PubMed
  25. Gastroenterol Res Pract. 2011;2011:917941 - PubMed
  26. Radiat Res. 1996 Aug;146(2):123-30 - PubMed
  27. Ann N Y Acad Sci. 1992 Sep 30;669:7-20 - PubMed
  28. Radiat Res. 2004 May;161(5):560-7 - PubMed
  29. BMC Cancer. 2004 Dec 15;4:92 - PubMed
  30. JAMA. 2002 Jun 19;287(23):3116-26 - PubMed
  31. Sci Transl Med. 2014 Jul 16;6(245):245ra93 - PubMed
  32. Cancer Lett. 2012 Dec 31;327(1-2):48-60 - PubMed
  33. Biochem J. 2000 Apr 1;347 Pt 1:1-16 - PubMed
  34. Cell Res. 2007 Sep;17(9):759-71 - PubMed
  35. Toxicol Pathol. 2007 Jun;35(4):495-516 - PubMed
  36. Scand J Gastroenterol Suppl. 1971;12:1-52 - PubMed
  37. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):103-18 - PubMed
  38. Radiology. 1963 Feb;80:292-4 - PubMed
  39. Genes Dev. 2002 Oct 15;16(20):2662-71 - PubMed
  40. Oncogene. 1999 Dec 13;18(53):7644-55 - PubMed
  41. Clin Nutr. 1993 Apr;12(2):89-95 - PubMed
  42. Genes Dev. 1998 Sep 15;12(18):2831-41 - PubMed
  43. Transl Cancer Res. 2013 Oct;2(5):412-421 - PubMed
  44. Clin Nutr. 1992 Jun;11(3):147-53 - PubMed
  45. J Nutr Biochem. 2012 Jan;23(1):93-100 - PubMed
  46. Cold Spring Harb Perspect Biol. 2013 Apr 01;5(4):a008656 - PubMed
  47. Therap Adv Gastroenterol. 2010 Nov;3(6):359-65 - PubMed
  48. Curr Gastroenterol Rep. 2002 Oct;4(5):361-5 - PubMed
  49. Nature. 2000 Oct 12;407(6805):777-83 - PubMed
  50. Am J Clin Nutr. 2001 Dec;74(6):714-22 - PubMed
  51. Rep Pract Oncol Radiother. 2011 Jul 06;16(4):123-30 - PubMed
  52. Nat Rev Mol Cell Biol. 2008 May;9(5):402-12 - PubMed
  53. Nature. 2000 Oct 12;407(6805):770-6 - PubMed
  54. Biomolecules. 2015 Apr 15;5(2):472-84 - PubMed
  55. Cent Afr J Med. 1968 Dec;14(12):284-6 contd - PubMed
  56. Clin Interv Aging. 2007;2(2):219-36 - PubMed
  57. Arch Surg. 1985 Nov;120(11):1225-8 - PubMed
  58. World J Gastroenterol. 2008 Dec 28;14(48):7289-301 - PubMed
  59. J Physiol. 2001 Sep 1;535(Pt 2):541-52 - PubMed
  60. Cell Death Differ. 2012 Dec;19(12):2040-8 - PubMed
  61. Am J Med. 1993 Oct;95(4):397-406 - PubMed
  62. Gastroenterology. 2012 Nov;143(5):1266-1276 - PubMed
  63. Oncogene. 1997 Jun 12;14(23):2759-66 - PubMed
  64. Mol Cell Biol. 2014 Jan;34(2):148-57 - PubMed
  65. Radiother Oncol. 2012 Dec;105(3):305-12 - PubMed
  66. West J Med. 1985 May;142(5):685-6 - PubMed
  67. Redox Biol. 2015 Dec;6:565-577 - PubMed
  68. Int J Cancer. 2001 Nov;94(4):545-50 - PubMed
  69. Br J Cancer Suppl. 1986;7:16-9 - PubMed
  70. Clin Cancer Res. 2009 Dec 1;15(23):7238-45 - PubMed
  71. PLoS One. 2013 Jul 25;8(7):e70479 - PubMed
  72. Gastroenterology. 2006 Sep;131(3):862-77 - PubMed
  73. Br Med J. 1897 Jul 31;2(1909):272-3 - PubMed
  74. FEBS Lett. 1998 Oct 2;436(2):256-8 - PubMed
  75. Antioxid Redox Signal. 2008 Aug;10(8):1343-74 - PubMed
  76. Oncogene. 2003 Sep 1;22(37):5834-47 - PubMed
  77. Protein Sci. 2004 Aug;13(8):1979-87 - PubMed
  78. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8 - PubMed
  79. Mol Cell Biol. 2001 Feb;21(4):1297-310 - PubMed
  80. Cardiovasc Res. 2004 Aug 15;63(3):487-99 - PubMed
  81. Radiat Res. 1963 Jan;18:106-19 - PubMed
  82. Gastroenterol Hepatol (N Y). 2007 Feb;3(2):112-22 - PubMed
  83. Experientia. 1971 Mar 15;27(3):319-21 - PubMed
  84. J Nucleic Acids. 2010 Dec 16;2010:592980 - PubMed
  85. Mol Cell. 1999 Mar;3(3):287-96 - PubMed
  86. Neoplasia. 2000 Jul-Aug;2(4):291-9 - PubMed
  87. J Carcinog. 2009;8:5 - PubMed
  88. Int J Radiat Biol. 2009 Jul;85(7):598-606 - PubMed
  89. Comp Biochem Physiol B Biochem Mol Biol. 1997 Nov;118(3):473-8 - PubMed
  90. Anticancer Res. 1992 May-Jun;12(3):599-606 - PubMed
  91. Neoplasia. 2004 Sep-Oct;6(5):423-31 - PubMed
  92. Cancer J Sci Am. 1999 Jul-Aug;5(4):194-204 - PubMed
  93. AACN Clin Issues. 1997 Nov;8(4):627-34 - PubMed
  94. Altern Med Rev. 1999 Oct;4(5):304-29 - PubMed
  95. FASEB J. 2004 May;18(7):816-27 - PubMed
  96. Transl Oncol. 2010 Feb;3(1):1-12 - PubMed
  97. Int J Cancer. 2008 Apr 1;122(7):1679-83 - PubMed
  98. EMBO Rep. 2011 Jan;12(1):77-83 - PubMed
  99. PLoS One. 2015 Apr 10;10(4):e0122511 - PubMed
  100. Trends Mol Med. 2011 Nov;17(11):668-76 - PubMed
  101. Case Rep Gastroenterol. 2012 May;6(2):319-27 - PubMed
  102. Carcinogenesis. 2000 Mar;21(3):485-95 - PubMed
  103. Radiat Res. 2004 Jan;161(1):48-55 - PubMed
  104. Mutagenesis. 2013 Mar;28(2):127-34 - PubMed
  105. Am J Ophthalmol. 1994 Dec 15;118(6):797-804 - PubMed
  106. Biochim Biophys Acta. 2011 Jun;1807(6):735-45 - PubMed
  107. Biomed Res Int. 2014;2014:761264 - PubMed
  108. J Cell Biol. 1997 Dec 1;139(5):1281-92 - PubMed
  109. Int J Radiat Biol. 2002 Dec;78(12):1149-57 - PubMed
  110. Int J Mol Sci. 2013 Nov 18;14(11):22678-96 - PubMed
  111. Oncogene. 1998 Dec 24;17(25):3287-99 - PubMed
  112. Micron. 2002;33(2):167-78 - PubMed
  113. Cancer. 2002 Sep 1;95(5):1151-63 - PubMed
  114. Gynecol Oncol. 1986 Mar;23(3):310-5 - PubMed
  115. Cell Prolif. 2009 Dec;42(6):731-50 - PubMed
  116. Int J Radiat Biol. 2013 Dec;89(12):1061-70 - PubMed
  117. Free Radic Biol Med. 2007 Jul 1;43(1):4-15 - PubMed
  118. Nat Rev Drug Discov. 2013 Jul;12(7):526-42 - PubMed
  119. Int J Radiat Biol. 1988 Dec;54(6):1041-51 - PubMed
  120. Altern Med Rev. 2000 Apr;5(2):152-63 - PubMed
  121. J Mol Biol. 1980 Nov 5;143(3):289-301 - PubMed
  122. Oncologist. 2010;15(4):360-71 - PubMed
  123. Int J Radiat Biol. 1990 Jan;57(1):185-99 - PubMed
  124. FASEB J. 1999 Jun;13(9):977-94 - PubMed
  125. Int J Radiat Oncol Biol Phys. 2002 Dec 1;54(5):1314-21 - PubMed
  126. Radiographics. 2000 Jan-Feb;20(1):67-81 - PubMed
  127. PLoS One. 2012;7(1):e29357 - PubMed
  128. Pharmacogn Rev. 2010 Jul;4(8):118-26 - PubMed
  129. Colorectal Dis. 2002 Jan;4(1):2-12 - PubMed
  130. Oncology (Williston Park). 1999 Jul;13(7):1003-8; discussion 1008, 1011-2 - PubMed
  131. Nat Rev Mol Cell Biol. 2014 Jan;15(1):19-33 - PubMed
  132. Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G166-73 - PubMed
  133. Altern Med Rev. 1999 Oct;4(5):303 - PubMed
  134. Mol Cancer Ther. 2002 Jun;1(8):639-49 - PubMed

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