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Okubo T, Hirashio S, Shimizu M, et al. Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury. CEN Case Rep. 2017;6(2):140-147doi: 10.1007/s13730-017-0261-6.
Okubo, T., Hirashio, S., Shimizu, M., Kuroda, Y., Doi, S., & Masaki, T. (2017). Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury. CEN case reports, 6(2), 140-147. https://doi.org/10.1007/s13730-017-0261-6
Okubo, Tomoe, et al. "Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury." CEN case reports vol. 6,2 (2017): 140-147. doi: https://doi.org/10.1007/s13730-017-0261-6
Okubo T, Hirashio S, Shimizu M, Kuroda Y, Doi S, Masaki T. Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury. CEN Case Rep. 2017 Nov;6(2):140-147. doi: 10.1007/s13730-017-0261-6. Epub 2017 Jun 07. PMID: 28593485; PMCID: PMC5694399.
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CEN Case Rep. 2017 Nov;6(2):140-147. doi: 10.1007/s13730-017-0261-6. Epub 2017 Jun 07.

Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury.

CEN case reports

Tomoe Okubo, Shuma Hirashio, Minako Shimizu, Yoshiaki Kuroda, Shigehiro Doi, Takao Masaki

Affiliations

  1. Department of Nephrology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 7348551, Japan.
  2. Department of Nephrology, National Hospital Organization Higashihiroshima Medical Center, Hiroshima, Japan.
  3. Department of Hematology, Hiroshima University Hospital, Hiroshima, Japan.
  4. Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.
  5. Department of Nephrology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 7348551, Japan. [email protected].

PMID: 28593485 PMCID: PMC5694399 DOI: 10.1007/s13730-017-0261-6

Abstract

Acute kidney injury (AKI) because of bilateral renal infiltration is an uncommon presentation of diffuse large B-cell lymphoma (DLBCL). A 52-year-old man presented to our institution with AKI and complaints of fatigue. Ultrasonography revealed a large, 15 cm granulomatous mass arising from the bilateral kidneys. The mass was biopsied laparoscopically, and histopathological analysis revealed evidence of DLBCL. The patient subsequently underwent R-CHOP therapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Chemotherapy resulted in a rapid decrease in mass size and improvement in kidney function. However, after five courses of R-CHOP, relapse was observed in the central nervous system, and the patient died 220 days after the initial onset of AKI. Post-mortem analysis of renal tissue confirmed the initial diagnosis of DLBCL-associated renal infiltration. To our knowledge, this is the first report of DLBCL presenting as bilateral renal infiltration and AKI.

Keywords: Acute kidney injury; Central nervous system relapse; Diffuse large B-cell lymphoma; Kidney infiltration

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