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Tomizawa M, Shinozaki F, Hasegawa R, et al. Immunosuppressive agents are associated with peptic ulcer bleeding. Exp Ther Med. 2017;13(5):1927-1931doi: 10.3892/etm.2017.4214.
Tomizawa, M., Shinozaki, F., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., & Ishige, N. (2017). Immunosuppressive agents are associated with peptic ulcer bleeding. Experimental and therapeutic medicine, 13(5), 1927-1931. https://doi.org/10.3892/etm.2017.4214
Tomizawa, Minoru, et al. "Immunosuppressive agents are associated with peptic ulcer bleeding." Experimental and therapeutic medicine vol. 13,5 (2017): 1927-1931. doi: https://doi.org/10.3892/etm.2017.4214
Tomizawa M, Shinozaki F, Hasegawa R, Shirai Y, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Immunosuppressive agents are associated with peptic ulcer bleeding. Exp Ther Med. 2017 May;13(5):1927-1931. doi: 10.3892/etm.2017.4214. Epub 2017 Mar 09. PMID: 28565788; PMCID: PMC5443275.
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Exp Ther Med. 2017 May;13(5):1927-1931. doi: 10.3892/etm.2017.4214. Epub 2017 Mar 09.

Immunosuppressive agents are associated with peptic ulcer bleeding.

Experimental and therapeutic medicine

Minoru Tomizawa, Fuminobu Shinozaki, Rumiko Hasegawa, Yoshinori Shirai, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige

Affiliations

  1. Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
  2. Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
  3. Department of Surgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
  4. Department of Neurology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
  5. Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
  6. Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
  7. Department of Neurosurgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.

PMID: 28565788 PMCID: PMC5443275 DOI: 10.3892/etm.2017.4214

Abstract

Peptic ulcer bleeding can be fatal. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppressive agents are administered for long-term usage. The present study assessed the association between peptic ulcer bleeding and administration of NSAIDs, corticosteroids and immunosuppressive agents. Furthermore, the efficacy of lowering the risk of peptic ulcer bleeding with proton pump inhibitors (PPI) and histamine 2 receptor antagonists (H2RA) was evaluated. Medical records were retrospectively analyzed for patients subjected to an upper gastrointestinal (GI) endoscopy performed at the National Hospital Organization Shimoshizu Hospital (Yotsukaido, Japan) from October 2014 to September 2015. During this period, a total of 1,023 patients underwent an upper GI endoscopy. A total of 1,023 patients, including 431 males (age, 68.1±12.9 years) and 592 females (age, 66.4±12.3 years), who had been administered NSAIDs, corticosteroids, immunosuppressive agents, PPIs and H2RAs, were respectively enrolled. Endoscopic findings of the patients were reviewed and their data were statistically analyzed. Logistic regression analysis was used to determine the odds ratio of peptic ulcer bleeding for each medication; immunosuppressive agents had an odds ratio of 5.83, which was larger than that for NSAIDs (4.77). The Wald test was applied to confirm the correlation between immunosuppressive agents and peptic ulcer bleeding. Furthermore, χ

Keywords: Wald test; corticosteroids; histamine type 2 receptor antagonists; immunosuppressive agents; logistic regression analysis; nonsteroidal anti-inflammatory drugs; proton pump inhibitor

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