Iran J Med Sci. 2017 May;42(3):266-274.
Antihypertensive Effects of Hydroalcoholic Extract of .
Iranian journal of medical sciences
Mohammad Reza Haydari, Mohammad Reza Panjeshahin, Elaheh Mashghoolozekr, Ali Akbar Nekooeian
Affiliations
Affiliations
- Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
- Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
PMID: 28533575
PMCID: PMC5429495
Abstract
BACKGROUND: Hawthorn species decreases blood pressure and relaxes precontracted vessels. This study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of
METHODS: Six groups of male Sprague-Dawley rats, each containing 6 to 8 rats, were studied. The groups comprised of one sham group and 5 renal artery-clipped groups. The sham group received vehicle (distilled water 0.5 ml/day) and the renal artery-clipped groups received vehicle or the extract at 5, 10, 20 or 30 mg/kg/day. Oral vehicle or extract was administered daily for 4 weeks following sham-operation or induction of hypertension. Systolic blood pressure and heart rate were measured weekly. Isolated aorta study was performed by last week and serum superoxide dismutase and glutathione reductase were measured. The findings were analyzed using one-way analysis of variance and Duncan's multiple range tests at P≤0.05 using SigmaStat software.
RESULTS: The data obtained after 4 weeks of treatment showed that the renal artery-clipped group receiving vehicle had significantly higher systolic blood pressure (P=0.002) and phenylephrine maximal response (P=0.01); and lower acetylcholine maximal response (P=0.01), serum superoxide dismutase (P=0.006) and serum glutathione reductase (P=0.006) than those of the sham group. The renal artery-clipped group receiving extract had significantly lower systolic blood pressure (P=0.03) and phenylephrine maximal response (P=0.01); and significantly higher acetylcholine maximal response (P=0.01), serum superoxide dismutase (P=0.015), and serum glutathione reductase (P=0.015) than those of the renal artery-clipped group receiving vehicle.
CONCLUSION: Our findings show that the hydroalcoholic extract of
Keywords: Crataegus; Hypertension; Nitric oxide; Oxidative stress; Renovascular
References
- Circulation. 2004 May 18;109(19):2357-62 - PubMed
- Hypertension. 1999 Oct;34(4 Pt 2):943-9 - PubMed
- Hypertension. 1996 Nov;28(5):732-7 - PubMed
- Circ Res. 2013 Jul 5;113(2):100-3 - PubMed
- Cardiovasc Res. 2006 Jul 15;71(2):247-58 - PubMed
- J Cell Physiol. 2000 Sep;184(3):409-20 - PubMed
- J Asian Nat Prod Res. 2014;16(9):953-62 - PubMed
- Hypertension. 1992 Dec;20(6):763-7 - PubMed
- Life Sci. 2000;67(2):121-31 - PubMed
- Life Sci. 2016 Apr 1;150:89-94 - PubMed
- Clin Exp Pharmacol Physiol. 1995 Sep;22(9):665-9 - PubMed
- Diabetes Res Clin Pract. 2006 Jul;73(1):1-7 - PubMed
- Saudi Med J. 2013 Feb;34(2):123-34 - PubMed
- Molecules. 2014 Dec 15;19(12):20962-74 - PubMed
- Am J Physiol. 1989 Jul;257(1 Pt 2):H33-7 - PubMed
- Hypertension. 1986 Jun;8(6 Pt 2):II61-6 - PubMed
- Phytomedicine. 2012 Jun 15;19(8-9):699-706 - PubMed
- Eur J Pharmacol. 1990 Dec 15;189(6):347-53 - PubMed
- Cardiovasc Drugs Ther. 2006 Jun;20(3):177-84 - PubMed
- J Nat Prod. 2007 Mar;70(3):461-77 - PubMed
- Hypertens Res. 2013 Sep;36(9):765-9 - PubMed
- Cardiovasc Res. 2011 Feb 15;89(3):492-8 - PubMed
- Phytother Res. 2013 Mar;27(3):330-7 - PubMed
- Braz J Med Biol Res. 2000 Jun;33(6):653-60 - PubMed
- Can J Cardiol. 2006 May 15;22(7):553-5 - PubMed
- Anatol J Cardiol. 2015 ;15(12 ):970-5 - PubMed
- Exp Clin Endocrinol Diabetes. 2015 Jun;123(6):325-35 - PubMed
- Phytother Res. 2006 Jan;20(1):66-70 - PubMed
- J Cardiovasc Pharmacol. 2009 Mar;53(3):253-60 - PubMed
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