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Teixeira CR, Bonotto ML, Lima JP, et al. Clinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil. Ann Gastroenterol. 2017;30(4):442-445doi: 10.20524/aog.2017.0151.
Teixeira, C. R., Bonotto, M. L., Lima, J. P., Figueiredo, L. F., Conrado, L., & Frasca, C. (2017). Clinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil. Annals of gastroenterology, 30(4), 442-445. https://doi.org/10.20524/aog.2017.0151
Teixeira, Cláudio R, et al. "Clinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil." Annals of gastroenterology vol. 30,4 (2017): 442-445. doi: https://doi.org/10.20524/aog.2017.0151
Teixeira CR, Bonotto ML, Lima JP, Figueiredo LF, Conrado L, Frasca C. Clinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil. Ann Gastroenterol. 2017;30(4):442-445. doi: 10.20524/aog.2017.0151. Epub 2017 Apr 27. PMID: 28655982; PMCID: PMC5479998.
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Ann Gastroenterol. 2017;30(4):442-445. doi: 10.20524/aog.2017.0151. Epub 2017 Apr 27.

Clinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil.

Annals of gastroenterology

Cláudio R Teixeira, Michele L Bonotto, Júlio P Lima, Luciana F Figueiredo, Leonardo Conrado, Carlos Frasca

Affiliations

  1. Department of Endoscopy, Moinhos de Vento Hospital (Cláudio R. Teixeira, Michele L. Bonotto, Júlio P. Lima, Luciana F. Figueiredo, Leonardo Conrado, Carlos Frasca).
  2. Gastroenterology Fundation of Rio Grande do Sul, Fugast, Endoscopy Unit (Michele L. Bonotto, Júlio P. Lima, Luciana F. Figueiredo, Leonardo Conrado, Carlos Frasca), Brazil.

PMID: 28655982 PMCID: PMC5479998 DOI: 10.20524/aog.2017.0151

Abstract

BACKGROUND: Colorectal cancer (CRC) screening programs based on the fecal occult blood test (FOBT) reduce CRC mortality. We carried out an observational prospective study to determine the accuracy of immunochemical FOBTs for the detection of CRC in individuals at average risk for the disease.

METHODS: This population-based study was performed between April 2015 and January 2016 in two gastroenterology referral centers in Southern Brazil. It included 1039 average-risk volunteers aged 50-75 years who were symptom-free for colonic disease. Participants underwent OC-Light immunochemical fecal occult blood test (i-FOBT, EIKEN chemical Co., Tokyo, Japan) as well as screening colonoscopy.

RESULTS: Nine hundred forty-eight (91.2%) of the 1039 participants completed and returned the i-FOBT (95% confidence interval [CI] 89.4-92.9). Among the 73 participants with a positive i-FOBT who underwent colonoscopy, advanced CRC was detected in 9 (12.3%). Two (2.7%) early CRCs, 7 (9.5%) high-grade dysplasia adenomas and 25 (34.2%) low-grade dysplasia adenomas were also diagnosed. Among the 243 negative i-FOBT cases who underwent colonoscopy, one (0.4%) advanced CRC and 91 (37.6%) low-grade dysplasia adenomas were detected. The detection rate of CRC considering the whole screened population (n=1039) was 1.05% (11/1039).

CONCLUSIONS: The i-FOBT test in the CRC screening programs in Brazil showed a high compliance and high detection rates for cancers and high-risk adenomas. The i-FOBT test is feasible for CRC screening in an average-risk population.

Keywords: Colorectal cancer; adenoma; colonoscopy; fecal immunochemical test; fecal occult blood test; screening

Conflict of interest statement

Conflict of Interest: Claudio Rolim Teixeira is a speaker/consultant of Fujifilm Co.

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