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Caldas RF, Oliveira P, Rodrigues C, et al. Intraplacental Choriocarcinoma: Rare or Underdiagnosed? Report of 2 Cases Diagnosed after an Incomplete Miscarriage and a Preterm Spontaneous Vaginal Delivery. Case Rep Med. 2017;2017:7892980doi: 10.1155/2017/7892980.
Caldas, R. F., Oliveira, P., Rodrigues, C., Reis, I., Scigliano, H., Nogueira, R., Araújo, C., & Ferreira, S. (2017). Intraplacental Choriocarcinoma: Rare or Underdiagnosed? Report of 2 Cases Diagnosed after an Incomplete Miscarriage and a Preterm Spontaneous Vaginal Delivery. Case reports in medicine, 20177892980. https://doi.org/10.1155/2017/7892980
Caldas, Rita Ferraz, et al. "Intraplacental Choriocarcinoma: Rare or Underdiagnosed? Report of 2 Cases Diagnosed after an Incomplete Miscarriage and a Preterm Spontaneous Vaginal Delivery." Case reports in medicine vol. 2017 (2017): 7892980. doi: https://doi.org/10.1155/2017/7892980
Caldas RF, Oliveira P, Rodrigues C, Reis I, Scigliano H, Nogueira R, Araújo C, Ferreira S. Intraplacental Choriocarcinoma: Rare or Underdiagnosed? Report of 2 Cases Diagnosed after an Incomplete Miscarriage and a Preterm Spontaneous Vaginal Delivery. Case Rep Med. 2017;2017:7892980. doi: 10.1155/2017/7892980. Epub 2017 Apr 16. PMID: 28567059; PMCID: PMC5439247.
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Case Rep Med. 2017;2017:7892980. doi: 10.1155/2017/7892980. Epub 2017 Apr 16.

Intraplacental Choriocarcinoma: Rare or Underdiagnosed? Report of 2 Cases Diagnosed after an Incomplete Miscarriage and a Preterm Spontaneous Vaginal Delivery.

Case reports in medicine

Rita Ferraz Caldas, Paula Oliveira, Cátia Rodrigues, Inês Reis, Horácio Scigliano, Rosete Nogueira, Célia Araújo, Soledade Ferreira

Affiliations

  1. Department of Obstetrics and Gynecology, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.
  2. Department of Anatomic Pathology Lab Albino Oliveira, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.
  3. Department of Anatomic, Cytopathology and Thanatology, Escola Superior de Saúde, Instituto Politécnico do Porto, Porto, Portugal.
  4. Department of Fetal Pathology and Anatomic Pathology Lab, CGC Genetics, Porto, Portugal.
  5. Life and Health Sciences Research Institute (ICVS), School of Medicine, ICVS/3B's-PT Government Associate Laboratory, Campus of Gualtar, University of Minho, Guimarães, Braga, Portugal.

PMID: 28567059 PMCID: PMC5439247 DOI: 10.1155/2017/7892980

Abstract

Intraplacental choriocarcinoma is a rare malignant tumor diagnosed after an abortion, an ectopic pregnancy, or a term or preterm pregnancy or following the diagnosis of a hydatidiform mole. During pregnancy, it may be more common than reported, as most patients are asymptomatic and placental choriocarcinomas are usually inconspicuous macroscopically and are often mistaken for an infarct. Based upon a case study methodology, we describe 2 cases of intraplacental choriocarcinoma: the first case was identified in the product of a uterine curettage following an incomplete miscarriage and the second in one of the placentas of a bichorionic twin pregnancy. Maternal investigation did not reveal evidence of metastatic disease and neither did the infants' one in the second case. The two cases underwent maternal surveillance with serum hCG and remained disease-free until the present. In conclusion, intraplacental choriocarcinoma is easily underdiagnosed but with current treatment, even in the presence of metastasis, the prognosis is excellent. A routine microscopic examination of all the placentas and products of miscarriage can increase the real incidence of this entity and consequently improve its management.

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