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Felisaz PF, Maugeri G, Busi V, et al. MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy. Radiol Res Pract. 2017;2017:2761818doi: 10.1155/2017/2761818.
Felisaz, P. F., Maugeri, G., Busi, V., Vitale, R., Balducci, F., Gitto, S., Leporati, P., Pichiecchio, A., Baldi, M., Calliada, F., Chiovato, L., & Bastianello, S. (2017). MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy. Radiology research and practice, 20172761818. https://doi.org/10.1155/2017/2761818
Felisaz, P F, et al. "MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy." Radiology research and practice vol. 2017 (2017): 2761818. doi: https://doi.org/10.1155/2017/2761818
Felisaz PF, Maugeri G, Busi V, Vitale R, Balducci F, Gitto S, Leporati P, Pichiecchio A, Baldi M, Calliada F, Chiovato L, Bastianello S. MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy. Radiol Res Pract. 2017;2017:2761818. doi: 10.1155/2017/2761818. Epub 2017 Apr 16. PMID: 28567306; PMCID: PMC5439248.
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Radiol Res Pract. 2017;2017:2761818. doi: 10.1155/2017/2761818. Epub 2017 Apr 16.

MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy.

Radiology research and practice

P F Felisaz, G Maugeri, V Busi, R Vitale, F Balducci, S Gitto, P Leporati, A Pichiecchio, M Baldi, F Calliada, L Chiovato, S Bastianello

Affiliations

  1. Radiology Department, University of Pavia, Pavia, Italy.
  2. Postgraduation School in Radiodiagnostics, Università degli Studi di Milano, Milan, Italy.
  3. Unit of Internal Medicine and Endocrinology, IRCCS Salvatore Maugeri Foundation, Scientific Institute of Pavia, Pavia, Italy.
  4. Neuroradiology Department, C. Mondino National Neurological Institute, Pavia, Italy.
  5. Radiology Department, IRCCS Salvatore Maugeri Foundation, Scientific Institute of Pavia, Pavia, Italy.
  6. Institute of Radiology, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
  7. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

PMID: 28567306 PMCID: PMC5439248 DOI: 10.1155/2017/2761818

Abstract

The aim of this study was to assess with MRI morphometric ultrastructural changes in nerves affected by diabetic peripheral neuropathy (DPN). We used an MR micro-neurography imaging protocol and a semiautomated technique of tissue segmentation to visualize and measure the volume of internal nerve components, such as the epineurium and nerve fascicles. The tibial nerves of 16 patients affected by DPN and of 15 healthy volunteers were imaged. Nerves volume (NV), fascicles volume (FV), fascicles to nerve ratio (FNR), and nerves cross-sectional areas (CSA) were obtained. In patients with DPN the NV was increased and the FNR was decreased, as a result of an increase of the epineurium (FNR in diabetic neuropathy 0,665; in controls 0,699,

Conflict of interest statement

The authors declare that they have no conflict of interests regarding the publication of this paper.

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