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Waldman AT, Liu GT, Lavery AM, et al. Optical coherence tomography and visual evoked potentials in pediatric MS. Neurol Neuroimmunol Neuroinflamm. 2017;4(4):e356doi: 10.1212/NXI.0000000000000356.
Waldman, A. T., Liu, G. T., Lavery, A. M., Liu, G., Gaetz, W., Aleman, T. S., & Banwell, B. L. (2017). Optical coherence tomography and visual evoked potentials in pediatric MS. Neurology(R) neuroimmunology & neuroinflammation, 4(4), e356. https://doi.org/10.1212/NXI.0000000000000356
Waldman, Amy T, et al. "Optical coherence tomography and visual evoked potentials in pediatric MS." Neurology(R) neuroimmunology & neuroinflammation vol. 4,4 (2017): e356. doi: https://doi.org/10.1212/NXI.0000000000000356
Waldman AT, Liu GT, Lavery AM, Liu G, Gaetz W, Aleman TS, Banwell BL. Optical coherence tomography and visual evoked potentials in pediatric MS. Neurol Neuroimmunol Neuroinflamm. 2017 Jun 05;4(4):e356. doi: 10.1212/NXI.0000000000000356. eCollection 2017 Jul. PMID: 28626779; PMCID: PMC5459791.
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Neurol Neuroimmunol Neuroinflamm. 2017 Jun 05;4(4):e356. doi: 10.1212/NXI.0000000000000356. eCollection 2017 Jul.

Optical coherence tomography and visual evoked potentials in pediatric MS.

Neurology(R) neuroimmunology & neuroinflammation

Amy T Waldman, Grant T Liu, Amy M Lavery, Geraldine Liu, William Gaetz, Tomas S Aleman, Brenda L Banwell

Affiliations

  1. Division of Neurology (A.T.W., A.M.L., G.L., B.L.B.), Neuro-ophthalmology Service (G.T.L.), Division of Ophthalmology, and Division of Radiology (W.G.), Children's Hospital of Philadelphia, PA; and Departments of Neurology (A.T.W., B.L.B., G.T.L.), Pediatrics (A.T.W., B.L.B.), and Ophthalmology (G.T.L., T.S.A.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

PMID: 28626779 PMCID: PMC5459791 DOI: 10.1212/NXI.0000000000000356

Abstract

OBJECTIVE: To determine the relative ability of optical coherence tomography (OCT) and pattern-reversal visual evoked potentials (pVEPs) to detect visual pathway involvement in pediatric-onset MS.

METHODS: Pediatric-onset MS participants (onset <18 years) and healthy controls (HCs) underwent OCT (Cirrus HD-OCT) and pVEPs. Retinal nerve fiber layer (RNFL), ganglion cell layer to inner plexiform layer (GCL-IPL), and P100 pVEP latency were measured. Generalized estimating equation models were used to compare the groups, adjusting for age and intereye correlations.

RESULTS: Twenty-four pediatric MS participants, 14 with a history of remote (>6 months) optic neuritis (ON) in one eye (8 participants) or both the eyes (6 participants), and 24 HCs were enrolled. RNFL thinning (<83 μm, 2 SDs below HC eyes) occurred in 50% of ON eyes vs 5% of non-ON eyes. Prolonged VEP latency (>109 msec) occurred in 58% of ON eyes and 55% of non-ON eyes. A clinical history of ON predicted RNFL (

CONCLUSIONS: OCT and pVEPs provide complementary but distinct insights. OCT is sensitive to retinal changes in the context of clinical ON, whereas pVEPs are useful to detect disseminated lesions of the visual pathway in children with MS.

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