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Lashay A, Mirshahi A, Parandin N, et al. A prospective randomized trial of azithromycin versus trimethoprim/sulfamethoxazole in treatment of toxoplasmic retinochoroiditis. J Curr Ophthalmol. 2016;29(2):120-125doi: 10.1016/j.joco.2016.10.002.
Lashay, A., Mirshahi, A., Parandin, N., Riazi Esfahani, H., Mazloumi, M., Reza Lashay, M., Johari, M. K., & Ashrafi, E. (2017). A prospective randomized trial of azithromycin versus trimethoprim/sulfamethoxazole in treatment of toxoplasmic retinochoroiditis. Journal of current ophthalmology, 29(2), 120-125. https://doi.org/10.1016/j.joco.2016.10.002
Lashay, Alireza, et al. "A prospective randomized trial of azithromycin versus trimethoprim/sulfamethoxazole in treatment of toxoplasmic retinochoroiditis." Journal of current ophthalmology vol. 29,2 (2017): 120-125. doi: https://doi.org/10.1016/j.joco.2016.10.002
Lashay A, Mirshahi A, Parandin N, Riazi Esfahani H, Mazloumi M, Reza Lashay M, Johari MK, Ashrafi E. A prospective randomized trial of azithromycin versus trimethoprim/sulfamethoxazole in treatment of toxoplasmic retinochoroiditis. J Curr Ophthalmol. 2016 Dec 28;29(2):120-125. doi: 10.1016/j.joco.2016.10.002. eCollection 2017 Jun. PMID: 28626822; PMCID: PMC5463001.
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J Curr Ophthalmol. 2016 Dec 28;29(2):120-125. doi: 10.1016/j.joco.2016.10.002. eCollection 2017 Jun.

A prospective randomized trial of azithromycin versus trimethoprim/sulfamethoxazole in treatment of toxoplasmic retinochoroiditis.

Journal of current ophthalmology

Alireza Lashay, Ahmad Mirshahi, Najaf Parandin, Hamid Riazi Esfahani, Mehdi Mazloumi, Mohammad Reza Lashay, Mohammad Karim Johari, Elham Ashrafi

Affiliations

  1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 28626822 PMCID: PMC5463001 DOI: 10.1016/j.joco.2016.10.002

Abstract

PURPOSE: To assess the efficacy of oral azithromycin in the treatment of toxoplasmic retinochoroiditis.

METHODS: A randomized interventional comparative study was conducted on 14 patients with ocular toxoplasmosis who were treated with oral azithromycin and 13 patients who were treated with oral trimethoprim/sulfamethoxazole for 6-12 weeks. The achievement of treatment criteria in the two groups and lesion size reduction were considered as primary outcome measures.

RESULTS: The resolution of inflammatory activity, decrease in the size of retinochoroidal lesions, and final best corrected visual acuity (BCVA) did not differ between the two treatment groups. The lesion size declined significantly in all patients (

CONCLUSIONS: Drug efficacy in terms of reducing the size of retinal lesions and visual improvement was similar in a regimen of trimethoprim/sulfamethoxazole or azithromycin treatment. Therefore, if confirmed with further studies, therapy with azithromycin seems to be an acceptable alternative for the treatment of ocular toxoplasmosis.

Keywords: Azithromycin; Toxoplasmic retinochoroiditis; Trimethoprim/sulfamethoxazole

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