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Mecklenburg J, Patil MJ, Koek W, et al. Effects of local and spinal administrations of mu-opioids on postoperative pain in aged versus adult mice. Pain Rep. 2017;2(1):e584doi: 10.1097/PR9.0000000000000584.
Mecklenburg, J., Patil, M. J., Koek, W., & Akopian, A. N. (2017). Effects of local and spinal administrations of mu-opioids on postoperative pain in aged versus adult mice. Pain reports, 2(1), e584. https://doi.org/10.1097/PR9.0000000000000584
Mecklenburg, Jennifer, et al. "Effects of local and spinal administrations of mu-opioids on postoperative pain in aged versus adult mice." Pain reports vol. 2,1 (2017): e584. doi: https://doi.org/10.1097/PR9.0000000000000584
Mecklenburg J, Patil MJ, Koek W, Akopian AN. Effects of local and spinal administrations of mu-opioids on postoperative pain in aged versus adult mice. Pain Rep. 2017 Jan;2(1):e584. doi: 10.1097/PR9.0000000000000584. PMID: 28626834; PMCID: PMC5469295.
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Pain Rep. 2017 Jan;2(1):e584. doi: 10.1097/PR9.0000000000000584.

Effects of local and spinal administrations of mu-opioids on postoperative pain in aged versus adult mice.

Pain reports

Jennifer Mecklenburg, Mayur J Patil, Wouter Koek, Armen N Akopian

Affiliations

  1. Department of Endodontics, School of Dentistry, UT Health Science Center, San Antonio, TX, USA.
  2. Department of Psychiatry, School of Medicine, UT Health Science Center, San Antonio, TX, USA.
  3. Department of Pharmacology, UT Health Science Center, San Antonio, TX, USA.

PMID: 28626834 PMCID: PMC5469295 DOI: 10.1097/PR9.0000000000000584

Abstract

INTRODUCTION: Suboptimal management of postoperative pain leads to increased risk of chronic opioid therapy, especially in elderly patients.

OBJECTIVES: Although this age-dependent phenomenon has been observed clinically, basic mechanisms including baseline nociception, postoperative hypersensitivity, and mu-opioid efficiency in aged animals have never been evaluated.

METHODS: We tested these criteria using incision model on adult (3–6 months) and aged (24 months) mice to assess translatability of postoperative animal studies to clinical observations.

RESULTS: Thermal and mechanical testing revealed lower baseline nociception in aged vs adult mice, while behavioral assays after hind paw plantar incision showed similar hypersensitivity levels for both age groups. Efficiency of local and spinal mu-opioid injections on postoperative pain was assessed next. DAMGO, a pure mu-opioid, was effective in reducing postoperative hypersensitivity in aged and adult mice, although adult mice displayed increased sensitivity to higher doses (50 μg local; 1–15 μg spinal). Buprenorphine, a mixed mu-opioid agonist, produced dose-dependent antihypersensitivity with adult mice more sensitive to lower doses (0.1 μg local; 0.02 μg spinal), and aged mice more sensitive to higher doses (1, 10 μg local; 0.1, 1 μg spinal). Finally, exploratory locomotor activity was used to evaluate the suppression of incision-induced spontaneous pain by DAMGO. Spinal and systemic (intraperitoneal) DAMGO inhibited ongoing pain more in adults compared with aged mice.

CONCLUSION: As in humans, baseline nociception was lower in aged vs adult mice, while postoperative hypersensitivity magnitudes were comparable between groups. Unlike in humans, adult mice were more sensitive to mu-opioids, although higher doses of mixed mu-opioids were more effective for postoperative antihypersensitivity in aged mice.

Keywords: Postoperative pain; aged mice; buprenorphine; mu-opioids

Conflict of interest statement

The authors do not have any conflict of interest listed in “Instruction for Authors”.

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