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Chandak SA, Vanikar AV. Unusually Detected Anti-M Antibody Presenting as Cross Match Incompatibility in a Female Child Diagnosed with Small Round Cell Tumour. J Clin Diagn Res. 2017;11(5):ED20-ED21doi: 10.7860/JCDR/2017/25591.9862.
Chandak, S. A., & Vanikar, A. V. (2017). Unusually Detected Anti-M Antibody Presenting as Cross Match Incompatibility in a Female Child Diagnosed with Small Round Cell Tumour. Journal of clinical and diagnostic research : JCDR, 11(5), ED20-ED21. https://doi.org/10.7860/JCDR/2017/25591.9862
Chandak, Sheetal Anand, and Vanikar, Aruna Vishwanath. "Unusually Detected Anti-M Antibody Presenting as Cross Match Incompatibility in a Female Child Diagnosed with Small Round Cell Tumour." Journal of clinical and diagnostic research : JCDR vol. 11,5 (2017): ED20-ED21. doi: https://doi.org/10.7860/JCDR/2017/25591.9862
Chandak SA, Vanikar AV. Unusually Detected Anti-M Antibody Presenting as Cross Match Incompatibility in a Female Child Diagnosed with Small Round Cell Tumour. J Clin Diagn Res. 2017 May;11(5):ED20-ED21. doi: 10.7860/JCDR/2017/25591.9862. Epub 2017 May 01. PMID: 28658782; PMCID: PMC5483684.
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J Clin Diagn Res. 2017 May;11(5):ED20-ED21. doi: 10.7860/JCDR/2017/25591.9862. Epub 2017 May 01.

Unusually Detected Anti-M Antibody Presenting as Cross Match Incompatibility in a Female Child Diagnosed with Small Round Cell Tumour.

Journal of clinical and diagnostic research : JCDR

Sheetal Anand Chandak, Aruna Vishwanath Vanikar

Affiliations

  1. Assistant Professor, Department of Immunohaematology and Transfusion Sciences, Institute of Kidney Diseases and Transplantation Sciences, Ahmedabad, Gujarat, India.
  2. Professor and Head, Department of Cell Therapy and Regenerative Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, Gujarat, India.

PMID: 28658782 PMCID: PMC5483684 DOI: 10.7860/JCDR/2017/25591.9862

Abstract

MNS antigen system is one of the human blood group systems. Anti-M antibody is a relatively common, naturally occurring antibody of IgM variety. Clinically significant anti-M antibody is reactive at 37°C in the anti-human globulin phase due to high thermal amplitude of IgM component or presence of IgG component. If anti-M antibody is activated at 37°C or in the anti-human globulin phase, it may cause delayed haemolytic transfusion reactions or haemolytic disease of newborn, which suggest variable clinical significance. We report a case of an unusually detected anti-M antibody presenting as cross match incompatibility in a one-year-old female child with a lump in the right lumbar region, which was later diagnosed as small round cell tumour in the right kidney.

Keywords: Agglutination; Blood group; Thermal amplitude

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