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Pavanello S, Stendardo M, Mastrangelo G, et al. Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers. Front Immunol. 2017;8:516doi: 10.3389/fimmu.2017.00516.
Pavanello, S., Stendardo, M., Mastrangelo, G., Bonci, M., Bottazzi, B., Campisi, M., Nardini, M., Leone, R., Mantovani, A., & Boschetto, P. (2017). Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers. Frontiers in immunology, 8516. https://doi.org/10.3389/fimmu.2017.00516
Pavanello, Sofia, et al. "Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers." Frontiers in immunology vol. 8 (2017): 516. doi: https://doi.org/10.3389/fimmu.2017.00516
Pavanello S, Stendardo M, Mastrangelo G, Bonci M, Bottazzi B, Campisi M, Nardini M, Leone R, Mantovani A, Boschetto P. Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers. Front Immunol. 2017 May 09;8:516. doi: 10.3389/fimmu.2017.00516. eCollection 2017. PMID: 28536575; PMCID: PMC5422482.
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Front Immunol. 2017 May 09;8:516. doi: 10.3389/fimmu.2017.00516. eCollection 2017.

Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers.

Frontiers in immunology

Sofia Pavanello, Mariarita Stendardo, Giuseppe Mastrangelo, Melissa Bonci, Barbara Bottazzi, Manuela Campisi, Marco Nardini, Roberto Leone, Alberto Mantovani, Piera Boschetto

Affiliations

  1. Occupational Medicine, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
  2. Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
  3. Laboratory of Research in Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
  4. Department of Prevention and Protection, University-Hospital and Public Health Service of Ferrara, Ferrara, Italy.
  5. Humanitas University, Rozzano, Milan, Italy.

PMID: 28536575 PMCID: PMC5422482 DOI: 10.3389/fimmu.2017.00516

Abstract

Aging is an emerging worldwide threat to public health, even in the workplace, as it links with risk of illness and death. Bewildered inflammatory responses and stressful conditions associate with age-related disorders. Additionally, circadian rhythm disruption, a critical health issue in night-shift workers, correlates with premature aging. We investigated the hypothesis of a link between altered inflammatory response, detected by plasmatic long pentraxin 3 (PTX3), and biological aging, measured by leukocyte telomere length (LTL), attrition, and possibly induced by night-shift work. Within the framework of a cross-sectional study, such possible relationships were appraised by simultaneous equation model (SEM) technique among day and night-shift hospital workers. PTX3 levels, modulated by several aging conditions [i.e., body mass index (BMI) (beta = -0.22;

Keywords: aging; circadian rhythm; genetic instability; inflammation; night-shift work; pentraxin 3; premature; telomere

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