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Hasosah M, Alsaleem K, Qurashi M, et al. Neonatal Hyperthyroidism with Fulminant Liver Failure: A Case Report. J Clin Diagn Res. 2017;11(4):SD01-SD02doi: 10.7860/JCDR/2017/21503.9641.
Hasosah, M., Alsaleem, K., Qurashi, M., & Alzaben, A. (2017). Neonatal Hyperthyroidism with Fulminant Liver Failure: A Case Report. Journal of clinical and diagnostic research : JCDR, 11(4), SD01-SD02. https://doi.org/10.7860/JCDR/2017/21503.9641
Hasosah, Mohammed, et al. "Neonatal Hyperthyroidism with Fulminant Liver Failure: A Case Report." Journal of clinical and diagnostic research : JCDR vol. 11,4 (2017): SD01-SD02. doi: https://doi.org/10.7860/JCDR/2017/21503.9641
Hasosah M, Alsaleem K, Qurashi M, Alzaben A. Neonatal Hyperthyroidism with Fulminant Liver Failure: A Case Report. J Clin Diagn Res. 2017 Apr;11(4):SD01-SD02. doi: 10.7860/JCDR/2017/21503.9641. Epub 2017 Apr 01. PMID: 28571223; PMCID: PMC5449869.
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J Clin Diagn Res. 2017 Apr;11(4):SD01-SD02. doi: 10.7860/JCDR/2017/21503.9641. Epub 2017 Apr 01.

Neonatal Hyperthyroidism with Fulminant Liver Failure: A Case Report.

Journal of clinical and diagnostic research : JCDR

Mohammed Hasosah, Khalid Alsaleem, Mansour Qurashi, Abdullah Alzaben

Affiliations

  1. Paediatric Consultant, Department of Paediatrics, King Saud Bin Abdulaziz University for Health Sciences, National Guard Hospital, Jeddah, Saudi Arabia.
  2. Paediatric Consultant, Department of Paediatrics, Division of Gastroenterology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  3. Paediatric Consultant, Department of Paediatrics, King Saud Bin Abdulaziz University for Health Sciences, National Guard Hospital, Riyadh, Saudi Arabia.

PMID: 28571223 PMCID: PMC5449869 DOI: 10.7860/JCDR/2017/21503.9641

Abstract

Neonatal hyperthyroidism is a rare disease that is seen in infants born to mothers with Graves' disease. Hepatic manifestation of neonatal hyperthyroidism is extremely rare. We describe a neonate with fulminant liver failure secondary to neonatal hyperthyroidism caused by maternal Graves's disease. The baby was admitted with low birth weight and hepatosplenomegaly. At day 2 of life, the baby was irritable and he developed respiratory distress and fulminant hepatic failure which required mechanical ventilation. All investigations of obstructive, infectious and metabolic causes of hepatic failure were negative. His hepatic dysfunction improvement was correlated with initiation carbimazole as anti-thyroid medication. The conjugated hyperbilirubinemia, liver enzymes and International Normalised Ratio (INR) were gradually improved with normalization by eight weeks. This case has been reported to illustrate lessons learnt for early identification of neonate with hyperthyroidism as potential cause of cholestasis is important, because delayed treatment of hyperthyroidism might lead to irreversible consequences such as mental retardation or even death due to liver failure.

Keywords: Cholestasis; Graves’ disease; Liver diseases

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