Display options
Cite
Jung TY, Kim IY, Lim SH, et al. Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected . EJNMMI Res. 2017;7(1):45doi: 10.1186/s13550-017-0293-0.
Jung, T. Y., Kim, I. Y., Lim, S. H., Park, K. S., Kim, D. Y., Jung, S., Moon, K. S., Jang, W. Y., Kang, S. R., Cho, S. G., Min, J. J., Bom, H. S., & Kwon, S. Y. (2017). Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected . EJNMMI research, 7(1), 45. https://doi.org/10.1186/s13550-017-0293-0
Jung, Tae-Young, et al. "Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected ." EJNMMI research vol. 7,1 (2017): 45. doi: https://doi.org/10.1186/s13550-017-0293-0
Jung TY, Kim IY, Lim SH, Park KS, Kim DY, Jung S, Moon KS, Jang WY, Kang SR, Cho SG, Min JJ, Bom HS, Kwon SY. Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected . EJNMMI Res. 2017 Dec;7(1):45. doi: 10.1186/s13550-017-0293-0. Epub 2017 May 23. PMID: 28536967; PMCID: PMC5442037.
Copy Download .nbib Format: NLM
Share it on

EJNMMI Res. 2017 Dec;7(1):45. doi: 10.1186/s13550-017-0293-0. Epub 2017 May 23.

Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected .

EJNMMI research

Tae-Young Jung, In-Young Kim, Sa-Hoe Lim, Ki Seong Park, Dong-Yeon Kim, Shin Jung, Kyung-Sub Moon, Woo-Youl Jang, Sae-Ryung Kang, Sang-Geon Cho, Jung-Joon Min, Hee-Seung Bom, Seong Young Kwon

Affiliations

  1. Department of Neurosurgery, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeonnam, 58128, Republic of Korea.
  2. Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeonnam, 58128, Republic of Korea.
  3. Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeonnam, 58128, Republic of Korea. [email protected].

PMID: 28536967 PMCID: PMC5442037 DOI: 10.1186/s13550-017-0293-0

Abstract

BACKGROUND: Tumor to normal tissue ratio (T/N ratio) on

RESULTS: Among 77 lesions, 51 were diagnosed with recurrence. The mean T/N ratio was 2.25 (± 1.12) for recurrent lesions and 1.44 (± 0.22) for radiation necrosis (P < 0.001). T/N ratio of 1.61 (non-corrected) provided the best sensitivity, specificity, and diagnostic accuracy (70.6, 80.8, and 74.0%, respectively). Using the MTV criteria, optimal cutoff values of the T/N ratios in each group were 1.23 (MTV ≤ 0.5 cm

CONCLUSIONS: MTV-corrected cutoff values of T/N ratio could maintain the diagnostic performance of

Keywords: 11C-methionine PET/CT; Metabolic tumor volume; Metastatic brain tumor; Radiation necrosis; Recurrence

References

  1. Clin Cancer Res. 2004 Nov 1;10(21):7163-70 - PubMed
  2. Eur J Nucl Med Mol Imaging. 2010 Jan;37(1):84-92 - PubMed
  3. Eur J Nucl Med Mol Imaging. 2013 Apr;40(4):615-35 - PubMed
  4. J Korean Neurosurg Soc. 2013 Aug;54(2):107-11 - PubMed
  5. J Neurooncol. 1996 Feb;27(2):163-71 - PubMed
  6. Nucl Med Mol Imaging. 2015 Dec;49(4):291-7 - PubMed
  7. Mol Imaging. 2012 Nov-Dec;11(6):516-27 - PubMed
  8. N Engl J Med. 2010 Mar 25;362(12):1119-27 - PubMed
  9. J Nucl Med. 2008 May;49(5):694-9 - PubMed
  10. Clin Nucl Med. 2014 Nov;39(11):939-43 - PubMed
  11. Acta Radiol. 1991 May;32(3):197-202 - PubMed
  12. Neurosurg Rev. 2017 Apr;40(2):223-229 - PubMed
  13. Clin Nucl Med. 2012 Feb;37(2):158-63 - PubMed
  14. Neuro Oncol. 2013 May;15(5):515-34 - PubMed
  15. Ann Nucl Med. 2011 Apr;25(3):213-20 - PubMed
  16. PLoS One. 2015 Jul 13;10 (7):e0132515 - PubMed
  17. J Comput Assist Tomogr. 1979 Jun;3(3):299-308 - PubMed
  18. Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1339-49 - PubMed
  19. J Nucl Med. 2007 Jun;48(6):932-45 - PubMed
  20. J Neurosurg. 2003 May;98 (5):1056-64 - PubMed
  21. Ann Nucl Med. 2004 Jun;18(4):291-6 - PubMed

Publication Types