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Simon F, Tapia P, Armisen R, et al. Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca. Front Physiol. 2017;8:379doi: 10.3389/fphys.2017.00379.
Simon, F., Tapia, P., Armisen, R., Echeverria, C., Gatica, S., Vallejos, A., Pacheco, A., Sanhueza, M. E., Alvo, M., Segovia, E., & Torres, R. (2017). Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca. Frontiers in physiology, 8379. https://doi.org/10.3389/fphys.2017.00379
Simon, Felipe, et al. "Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca." Frontiers in physiology vol. 8 (2017): 379. doi: https://doi.org/10.3389/fphys.2017.00379
Simon F, Tapia P, Armisen R, Echeverria C, Gatica S, Vallejos A, Pacheco A, Sanhueza ME, Alvo M, Segovia E, Torres R. Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca. Front Physiol. 2017 Jun 13;8:379. doi: 10.3389/fphys.2017.00379. eCollection 2017. PMID: 28659813; PMCID: PMC5468383.
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Front Physiol. 2017 Jun 13;8:379. doi: 10.3389/fphys.2017.00379. eCollection 2017.

Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca.

Frontiers in physiology

Felipe Simon, Pablo Tapia, Ricardo Armisen, Cesar Echeverria, Sebastian Gatica, Alejandro Vallejos, Alejandro Pacheco, Maria E Sanhueza, Miriam Alvo, Erico Segovia, Rubén Torres

Affiliations

  1. Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas and Facultad de Medicina, Universidad Andres BelloSantiago, Chile.
  2. Millennium Institute on Immunology and ImmunotherapySantiago, Chile.
  3. Unidad de Paciente Critico, Hospital Clínico Metropolitano de La FloridaSantiago, Chile.
  4. Centro de Investigación y Tratamiento del Cancer, Facultad de Medicina, Universidad de ChileSantiago, Chile.
  5. Center for Excellence in Precision Medicine Pfizer, Pfizer ChileSantiago, Chile.
  6. Centro Integrativo de Biología y Química Aplicada, Universidad Bernardo OHigginsSantiago, Chile.
  7. Sección de Nefrología, Departamento de Medicina, Hospital Clínico Universidad de ChileSantiago, Chile.
  8. Facultad de Medicina, Instituto de Ciencias Biomédicas, Universidad de ChileSantiago, Chile.

PMID: 28659813 PMCID: PMC5468383 DOI: 10.3389/fphys.2017.00379

Abstract

Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritoneal cavity to generate an osmotic gradient that promotes water and solutes transport from peritoneal blood to the dialysis solution. Unfortunately, PD has been associated with a loss of peritoneal viability and function through the generation of a severe inflammatory state that induces human peritoneal mesothelial cell (HPMC) death. Despite this deleterious effect, the precise molecular mechanism of HPMC death as induced by HGH solutions is far from being understood. Therefore, the aim of this study was to explore the pathways involved in HGH solution-induced HPMC death. HGH-induced HPMC death included influxes of intracellular Ca

Keywords: cell death; dialysis; hypertonicity; mesothelial cell; peritoneal tissue

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