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Alunno A, Bistoni O, Manetti M, et al. Insulin-Like Growth Factor Binding Protein 6 in Rheumatoid Arthritis: A Possible Novel Chemotactic Factor?. Front Immunol. 2017;8:554doi: 10.3389/fimmu.2017.00554.
Alunno, A., Bistoni, O., Manetti, M., Cafaro, G., Valentini, V., Bartoloni, E., Gerli, R., & Liso, A. (2017). Insulin-Like Growth Factor Binding Protein 6 in Rheumatoid Arthritis: A Possible Novel Chemotactic Factor?. Frontiers in immunology, 8554. https://doi.org/10.3389/fimmu.2017.00554
Alunno, Alessia, et al. "Insulin-Like Growth Factor Binding Protein 6 in Rheumatoid Arthritis: A Possible Novel Chemotactic Factor?." Frontiers in immunology vol. 8 (2017): 554. doi: https://doi.org/10.3389/fimmu.2017.00554
Alunno A, Bistoni O, Manetti M, Cafaro G, Valentini V, Bartoloni E, Gerli R, Liso A. Insulin-Like Growth Factor Binding Protein 6 in Rheumatoid Arthritis: A Possible Novel Chemotactic Factor?. Front Immunol. 2017 May 18;8:554. doi: 10.3389/fimmu.2017.00554. eCollection 2017. PMID: 28572803; PMCID: PMC5435743.
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Front Immunol. 2017 May 18;8:554. doi: 10.3389/fimmu.2017.00554. eCollection 2017.

Insulin-Like Growth Factor Binding Protein 6 in Rheumatoid Arthritis: A Possible Novel Chemotactic Factor?.

Frontiers in immunology

Alessia Alunno, Onelia Bistoni, Mirko Manetti, Giacomo Cafaro, Valentina Valentini, Elena Bartoloni, Roberto Gerli, Arcangelo Liso

Affiliations

  1. Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy.
  2. Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy.
  3. Department of Medicine and Surgery, University of Foggia, Foggia, Italy.

PMID: 28572803 PMCID: PMC5435743 DOI: 10.3389/fimmu.2017.00554

Abstract

OBJECTIVES: Immune cell migration from the bloodstream to target tissues is a hallmark of rheumatoid arthritis (RA) pathogenesis. The role of chemoattractants, mainly chemokines, and their possible targeting for therapeutic purposes have been under intense investigation over the last few years but the results were not as satisfactory as expected. The insulin-like growth factor binding protein 6 (IGFBP6), a direct inhibitor of insulin-like growth factor (IGF)-II, also exerts IGF-independent effects including tumor cell migration

METHODS: IGFBP6 was measured in RA patients and healthy donors (HD) sera by Luminex xMAP

RESULTS: We demonstrated that IGFBP6 is able to induce greater

CONCLUSION: Our findings suggest a pathogenic role of IGFBP6 in RA and support its possible targeting for therapeutic purposes.

Keywords: IGFBP6; cell migration; rheumatoid arthritis; synovial membrane

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