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Case Rep Nephrol. 2017;2017:8137078. doi: 10.1155/2017/8137078. Epub 2017 May 10.

Cisplatin-Induced Renal Salt Wasting Requiring over 12 Liters of 3% Saline Replacement.

Case reports in nephrology

Phuong-Chi Pham, Pavani Reddy, Shaker Qaqish, Ashvin Kamath, Johana Rodriguez, David Bolos, Martina Zalom, Phuong-Thu Pham

Affiliations

  1. Olive View-UCLA Medical Center, Division of Nephrology and Hypertension, Sylmar, CA 91342, USA.
  2. Olive View-UCLA Medical Center, Division of Hematology and Oncology, Sylmar, CA 91342, USA.
  3. Ronald Reagan UCLA Medical Center, Kidney Transplant, Los Angeles, CA 90095, USA.

PMID: 28573057 PMCID: PMC5442328 DOI: 10.1155/2017/8137078

Abstract

Cisplatin is known to induce Fanconi syndrome and renal salt wasting (RSW). RSW typically only requires transient normal saline (NS) support. We report a severe RSW case that required 12 liters of 3% saline. A 57-year-old woman with limited stage small cell cancer was admitted for cisplatin (80 mg/m

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