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Li D, Chang X, Connolly JJ, et al. A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling. Sci Rep. 2017;7(1):3847doi: 10.1038/s41598-017-01674-8.
Li, D., Chang, X., Connolly, J. J., Tian, L., Liu, Y., Bhoj, E. J., Robinson, N., Abrams, D., Li, Y. R., Bradfield, J. P., Kim, C. E., Li, J., Wang, F., Snyder, J., Lemma, M., Hou, C., Wei, Z., Guo, Y., Qiu, H., Mentch, F. D., Thomas, K. A., Chiavacci, R. M., Cone, R., Li, B., Sleiman, P. A., & Hakonarson, H. (2017). A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling. Scientific reports, 7(1), 3847. https://doi.org/10.1038/s41598-017-01674-8
Li, Dong, et al. "A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling." Scientific reports vol. 7,1 (2017): 3847. doi: https://doi.org/10.1038/s41598-017-01674-8
Li D, Chang X, Connolly JJ, Tian L, Liu Y, Bhoj EJ, Robinson N, Abrams D, Li YR, Bradfield JP, Kim CE, Li J, Wang F, Snyder J, Lemma M, Hou C, Wei Z, Guo Y, Qiu H, Mentch FD, Thomas KA, Chiavacci RM, Cone R, Li B, Sleiman PA, Hakonarson H. A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling. Sci Rep. 2017 Jun 19;7(1):3847. doi: 10.1038/s41598-017-01674-8. PMID: 28630421; PMCID: PMC5476671.
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Sci Rep. 2017 Jun 19;7(1):3847. doi: 10.1038/s41598-017-01674-8.

A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling.

Scientific reports

Dong Li, Xiao Chang, John J Connolly, Lifeng Tian, Yichuan Liu, Elizabeth J Bhoj, Nora Robinson, Debra Abrams, Yun R Li, Jonathan P Bradfield, Cecilia E Kim, Jin Li, Fengxiang Wang, James Snyder, Maria Lemma, Cuiping Hou, Zhi Wei, Yiran Guo, Haijun Qiu, Frank D Mentch, Kelly A Thomas, Rosetta M Chiavacci, Roger Cone, Bingshan Li, Patrick A Sleiman, Hakon Hakonarson

Affiliations

  1. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. [email protected].
  2. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  3. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
  4. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  5. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. [email protected].
  6. Department of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. [email protected].
  7. Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].

PMID: 28630421 PMCID: PMC5476671 DOI: 10.1038/s41598-017-01674-8

Abstract

We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that approached genome-wide significance (rs929626 in EBF1 (Early B-Cell Factor 1); P = 2.04 × 10

References

  1. Curr Psychiatry Rep. 2013 Dec;15(12):423 - PubMed
  2. Nat Med. 2000 Apr;6(4):470-3 - PubMed
  3. Eur Psychiatry. 2001 Feb;16(1):38-48 - PubMed
  4. Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 - PubMed
  5. Mol Psychiatry. 2014 Jun;19(6):724-32 - PubMed
  6. Eur J Hum Genet. 2015 Jun;23(6):854-62 - PubMed
  7. Clin Pharmacol Ther. 2012 Feb;91(2):181-8 - PubMed
  8. Semin Immunol. 2008 Aug;20(4):221-7 - PubMed
  9. Nat Genet. 2011 Sep 11;43(10):1005-11 - PubMed
  10. Mol Cell Biol. 2007 Jan;27(2):743-57 - PubMed
  11. Am J Clin Pathol. 2002 Oct;118(4):582-8 - PubMed
  12. Biol Psychiatry. 2010 Jan 1;67(1):71-7 - PubMed
  13. Endocrinology. 2010 Apr;151(4):1611-21 - PubMed
  14. Nature. 2012 Sep 6;489(7414):57-74 - PubMed
  15. Arch Gen Psychiatry. 2006 Mar;63(3):305-12 - PubMed
  16. J Clin Endocrinol Metab. 2009 Jun;94(6):2129-36 - PubMed
  17. Bone. 2009 Apr;44(4):537-46 - PubMed
  18. Br J Psychiatry. 2009 Nov;195(5):393-402 - PubMed
  19. Am J Psychiatry. 2008 Feb;165(2):245-50 - PubMed
  20. Mol Cell Biol. 2002 Nov;22(22):8015-25 - PubMed
  21. Mol Psychiatry. 2011 Sep;16(9):949-59 - PubMed
  22. Am J Hum Genet. 2007 Sep;81(3):559-75 - PubMed
  23. Clin Biochem. 2004 May;37(5):382-7 - PubMed
  24. Annu Rev Nutr. 2007;27:263-75 - PubMed
  25. Int J Eat Disord. 2009 Mar;42(2):97-103 - PubMed
  26. Mol Psychiatry. 2014 Oct;19(10):1085-94 - PubMed
  27. Arch Gen Psychiatry. 2010 Jul;67(7):701-11 - PubMed
  28. Nature. 2011 Sep 11;478(7367):103-9 - PubMed
  29. Lancet Psychiatry. 2015 Dec;2(12):1099-111 - PubMed
  30. Physiol Res. 1999;48(3):197-202 - PubMed
  31. Int J Child Adolesc health. 2009;2(2):153-164 - PubMed

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