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Bashir BA, Saeed OKA. Natural regulatory anticoagulants proteins among Sudanese patients with dengue virus infection. Int J Health Sci (Qassim). 2017;11(2):3-8
Bashir, B. A., & Saeed, O. K. A. (2017). Natural regulatory anticoagulants proteins among Sudanese patients with dengue virus infection. International journal of health sciences, 11(2), 3-8.
Bashir, Bashir Abdrhman, and Saeed, Osman Khalaf Allah. "Natural regulatory anticoagulants proteins among Sudanese patients with dengue virus infection." International journal of health sciences vol. 11,2 (2017): 3-8.
Bashir BA, Saeed OKA. Natural regulatory anticoagulants proteins among Sudanese patients with dengue virus infection. Int J Health Sci (Qassim). 2017 Apr-Jun;11(2):3-8. PMID: 28539856; PMCID: PMC5426412.
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Int J Health Sci (Qassim). 2017 Apr-Jun;11(2):3-8.

Natural regulatory anticoagulants proteins among Sudanese patients with dengue virus infection.

International journal of health sciences

Bashir Abdrhman Bashir, Osman Khalaf Allah Saeed

Affiliations

  1. Department of Hematology, Medical Laboratory Sciences Division, Port Sudan Ahlia College, Port Sudan, Sudan.
  2. Department of Internal Medicine, Faculty of Medicine, University of Gezira, Wad Madani, Sudan.

PMID: 28539856 PMCID: PMC5426412

Abstract

THE COAGULATION SYSTEM: Abnormalities in natural physiologic anticoagulants are observed in dengue infection. Laboratory values such as protein C (PC), protein S (PS), and antithrombin (AT) indicate this problem on the coagulation system in dengue. Recently, an interrelationship between dengue and the levels of natural anticoagulants has been observed.

OBJECTIVE: The study conducted to find out the effect of dengue on the natural anticoagulant proteins.

METHODS: A case-control study was conducted in Port Sudan Teaching Hospital from February 2013 to June 2014 for 334 cases of dengue caused by dengue virus, 217 (65%) males and 117 (35%) were females along with 101 cases of control 64 (63.4%) males and 37 (36.6%) were females. Laboratory-positive dengue cases were confirmed by immunoglobulin (Ig) M and IgG immune chromatography rapid test and the WHO criteria were used for classifying the dengue severity. Platelet count (PLT), plasma prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, D-dimer (DD), aspartate transaminase, alanine transaminase, PC, PS, and AT were performed.

RESULTS: Of 334, 289 patients had dengue fever (DF) and 45 patients had dengue hemorrhagic fever (DHF). Thrombocytopenia was present in 279 (83.5%). PLT was found to be significantly low in the case of dengue (

CONCLUSION: The findings of this study suggest that lower levels of these proteins in patients with dengue are attributed to disseminated intravascular coagulation.

Keywords: Antithrombin; D-dimer; Sudan; dengue; natural anticoagulants; protein C; protein S

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