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Kim S, Lee SY, Kim M, et al. Tardive Dystonia Related with Aripiprazole. Psychiatry Investig. 2017;14(3):380-382doi: 10.4306/pi.2017.14.3.380.
Kim, S., Lee, S. Y., Kim, M., & Lee, K. U. (2017). Tardive Dystonia Related with Aripiprazole. Psychiatry investigation, 14(3), 380-382. https://doi.org/10.4306/pi.2017.14.3.380
Kim, Sunghwan, et al. "Tardive Dystonia Related with Aripiprazole." Psychiatry investigation vol. 14,3 (2017): 380-382. doi: https://doi.org/10.4306/pi.2017.14.3.380
Kim S, Lee SY, Kim M, Lee KU. Tardive Dystonia Related with Aripiprazole. Psychiatry Investig. 2017 May;14(3):380-382. doi: 10.4306/pi.2017.14.3.380. Epub 2017 May 16. PMID: 28539959; PMCID: PMC5440443.
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Psychiatry Investig. 2017 May;14(3):380-382. doi: 10.4306/pi.2017.14.3.380. Epub 2017 May 16.

Tardive Dystonia Related with Aripiprazole.

Psychiatry investigation

Sunghwan Kim, Seung-Yup Lee, MinSeob Kim, Kyoung-Uk Lee

Affiliations

  1. Department of Psychiatry, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Republic of Korea.

PMID: 28539959 PMCID: PMC5440443 DOI: 10.4306/pi.2017.14.3.380

Abstract

Tardive dystonia is characterized by sustained, generally slow involuntary twisting movements. It is estimated to occur at a frequency of 1% to 4% among patients who are taking an antipsychotic agent. Unlike the first generation antipsychotics, the second generation antipsychotics are less likely to cause neuroleptic-induced movement disorder. For aripiprazole, only a few cases have been reported for tardive dystonia. We present a young male, who developed a severe tardive dystonia after taking aripiprazole for 5 years. The patient was admitted to for the treatment of both hisdystonic and psychotic symptoms. Olanzapine was administered instead of aripiprazole and while his psychotic symptoms improved, the dystonic symptoms were continued. Therefore, olanzapine was switched to clozapine while augmenting with benzodiazepine, anti-cholinergic, and ginko biloba to control his tardive dystonia. After 2 weeks of treatment, the dystonic movement decreased remarkably.

Keywords: Aripiprazole; Clozapine; Ginkgo biloba; Schizoaffective disorder; Tardive dystonia

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