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Biomed Opt Express. 2017 May 04;8(6):2835-2850. doi: 10.1364/BOE.8.002835. eCollection 2017 Jun 01.

Raman active components of skin cancer.

Biomedical optics express

Xu Feng, Austin J Moy, Hieu T M Nguyen, Jason Zhang, Matthew C Fox, Katherine R Sebastian, Jason S Reichenberg, Mia K Markey, James W Tunnell

Affiliations

  1. Department of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton Street C0800, Austin, TX 78712, USA.
  2. Medicine, Dell Medical School, The University of Texas at Austin, 1400 N IH-35 Suite C2-470, Austin, TX 78701, USA.

PMID: 28663910 PMCID: PMC5480433 DOI: 10.1364/BOE.8.002835

Abstract

Raman spectroscopy (RS) has shown great potential in noninvasive cancer screening. Statistically based algorithms, such as principal component analysis, are commonly employed to provide tissue classification; however, they are difficult to relate to the chemical and morphological basis of the spectroscopic features and underlying disease. As a result, we propose the first Raman biophysical model applied to

Keywords: (170.1610) Clinical applications; (170.1790) Confocal microscopy; (170.3880) Medical and biological imaging; (170.6510) Spectroscopy, tissue diagnostics; (300.6450) Spectroscopy, Raman

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