Display options
Cite
Grootendorst MR, Fitzgerald AJ, Brouwer de Koning SG, et al. Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue. Biomed Opt Express. 2017;8(6):2932-2945doi: 10.1364/BOE.8.002932.
Grootendorst, M. R., Fitzgerald, A. J., Brouwer de Koning, S. G., Santaolalla, A., Portieri, A., Van Hemelrijck, M., Young, M. R., Owen, J., Cariati, M., Pepper, M., Wallace, V. P., Pinder, S. E., & Purushotham, A. (2017). Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue. Biomedical optics express, 8(6), 2932-2945. https://doi.org/10.1364/BOE.8.002932
Grootendorst, Maarten R, et al. "Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue." Biomedical optics express vol. 8,6 (2017): 2932-2945. doi: https://doi.org/10.1364/BOE.8.002932
Grootendorst MR, Fitzgerald AJ, Brouwer de Koning SG, Santaolalla A, Portieri A, Van Hemelrijck M, Young MR, Owen J, Cariati M, Pepper M, Wallace VP, Pinder SE, Purushotham A. Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue. Biomed Opt Express. 2017 May 09;8(6):2932-2945. doi: 10.1364/BOE.8.002932. eCollection 2017 Jun 01. PMID: 28663917; PMCID: PMC5480440.
Copy Download .nbib Format: NLM
Share it on

Biomed Opt Express. 2017 May 09;8(6):2932-2945. doi: 10.1364/BOE.8.002932. eCollection 2017 Jun 01.

Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue.

Biomedical optics express

Maarten R Grootendorst, Anthony J Fitzgerald, Susan G Brouwer de Koning, Aida Santaolalla, Alessia Portieri, Mieke Van Hemelrijck, Matthew R Young, Julie Owen, Massi Cariati, Michael Pepper, Vincent P Wallace, Sarah E Pinder, Arnie Purushotham

Affiliations

  1. King's College London, Division of Cancer Studies, London, UK.
  2. Department of Breast Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  3. Contributed equally.
  4. School of Physics, University of Western Australia, Perth, Australia.
  5. Teraview Ltd., Cambridge, UK.
  6. King's College London, Division of Cancer Studies, King's Health Partners Cancer Biobank and Breast Pathology Research Group, London, UK.
  7. London Centre for Nanotechnology, University College London, UK.

PMID: 28663917 PMCID: PMC5480440 DOI: 10.1364/BOE.8.002932

Abstract

Since nearly 20% of breast-conserving surgeries (BCS) require re-operation, there is a clear need for developing new techniques to more accurately assess tumor resection margins intraoperatively. This study evaluates the diagnostic accuracy of a handheld terahertz pulsed imaging (TPI) system to discriminate benign from malignant breast tissue ex vivo. Forty six freshly excised breast cancer samples were scanned with a TPI handheld probe system, and histology was obtained for comparison. The image pixels on TPI were classified using (1) parameters in combination with support vector machine (SVM) and (2) Gaussian wavelet deconvolution in combination with Bayesian classification. The results were an accuracy, sensitivity, specificity of 75%, 86%, 66% for method 1, and 69%, 87%, 54% for method 2 respectively. This demonstrates the probe can discriminate invasive breast cancer from benign breast tissue with an encouraging degree of accuracy, warranting further study.

Keywords: (110.6795) Terahertz imaging; (170.3880) Medical and biological imaging; (170.6935) Tissue characterization

References

  1. Ann Surg Oncol. 2015 Oct;22(10 ):3356-62 - PubMed
  2. Cancer Res. 2015 Sep 15;75(18):3706-12 - PubMed
  3. PLoS One. 2013 Jul 26;8(7):e69906 - PubMed
  4. BMJ. 2012 Jul 12;345:e4505 - PubMed
  5. Ann Surg Oncol. 2012 Feb;19(2):541-7 - PubMed
  6. Am J Surg. 2009 Oct;198(4):566-74 - PubMed
  7. Ann Surg Oncol. 2014 Oct;21(10):3185-91 - PubMed
  8. Sci Transl Med. 2013 Jul 17;5(194):194ra93 - PubMed
  9. Ann Surg. 2017 Feb;265(2):300-310 - PubMed
  10. J Biomed Opt. 2012 Jan;17(1):016005 - PubMed
  11. AJR Am J Roentgenol. 1996 Nov;167(5):1261-5 - PubMed
  12. Nat Rev Clin Oncol. 2013 Sep;10(9):507-18 - PubMed
  13. Quant Imaging Med Surg. 2012 Mar;2(1):33-45 - PubMed
  14. Stat Methods Med Res. 2016 Mar 16;:null - PubMed
  15. Opt Express. 2009 Jul 20;17(15):12444-54 - PubMed
  16. Radiology. 2006 May;239(2):533-40 - PubMed
  17. J Biomed Opt. 2000 Apr;5(2):221-8 - PubMed
  18. Eur J Surg Oncol. 2016 Dec;42(12 ):1834-1840 - PubMed
  19. Breast Cancer Res. 2013;15(4):R61 - PubMed
  20. Eur J Surg Oncol. 2012 May;38(5):375-81 - PubMed
  21. IEEE Trans Biomed Eng. 2015 Feb;62(2):699-707 - PubMed
  22. Ann Surg Oncol. 2009 Oct;16(10):2682-90 - PubMed
  23. PLoS One. 2016 Jul 26;11(7):e0159860 - PubMed
  24. Lasers Surg Med. 2010 Jan;42(1):15-23 - PubMed
  25. J Clin Oncol. 2000 Apr;18(8):1668-75 - PubMed
  26. Cancer Res. 2009 Nov 15;69(22):8790-6 - PubMed
  27. Nat Rev Clin Oncol. 2015 Nov;12 (11):645-63 - PubMed
  28. BJOG. 2001 Jun;108(6):562-7 - PubMed

Publication Types