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Lee PY, Chin SF, Neoh HM, et al. Metaproteomic analysis of human gut microbiota: where are we heading?. J Biomed Sci. 2017;24(1):36doi: 10.1186/s12929-017-0342-z.
Lee, P. Y., Chin, S. F., Neoh, H. M., & Jamal, R. (2017). Metaproteomic analysis of human gut microbiota: where are we heading?. Journal of biomedical science, 24(1), 36. https://doi.org/10.1186/s12929-017-0342-z
Lee, Pey Yee, et al. "Metaproteomic analysis of human gut microbiota: where are we heading?." Journal of biomedical science vol. 24,1 (2017): 36. doi: https://doi.org/10.1186/s12929-017-0342-z
Lee PY, Chin SF, Neoh HM, Jamal R. Metaproteomic analysis of human gut microbiota: where are we heading?. J Biomed Sci. 2017 Jun 12;24(1):36. doi: 10.1186/s12929-017-0342-z. PMID: 28606141; PMCID: PMC5469034.
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J Biomed Sci. 2017 Jun 12;24(1):36. doi: 10.1186/s12929-017-0342-z.

Metaproteomic analysis of human gut microbiota: where are we heading?.

Journal of biomedical science

Pey Yee Lee, Siok-Fong Chin, Hui-Min Neoh, Rahman Jamal

Affiliations

  1. UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, 56000, Cheras, Kuala Lumpur, Malaysia.
  2. UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, 56000, Cheras, Kuala Lumpur, Malaysia. [email protected].

PMID: 28606141 PMCID: PMC5469034 DOI: 10.1186/s12929-017-0342-z

Abstract

The human gut is home to complex microbial populations that change dynamically in response to various internal and external stimuli. The gut microbiota provides numerous functional benefits that are crucial for human health but in the setting of a disturbed equilibrium, the microbial community can cause deleterious outcomes such as diseases and cancers. Characterization of the functional activities of human gut microbiota is fundamental to understand their roles in human health and disease. Metaproteomics, which refers to the study of the entire protein collection of the microbial community in a given sample is an emerging area of research that provides informative details concerning functional aspects of the microbiota. In this mini review, we present a summary of the progress of metaproteomic analysis for studying the functional role of gut microbiota. This is followed by an overview of the experimental approaches focusing on fecal specimen for metaproteomics and is concluded by a discussion on the challenges and future directions of metaproteomic research.

Keywords: Gut Microbiota; Human; Metaproteomics; Multi-omics; Technologies

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