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David A, Mari C, Vignaud F, et al. Evaluation of S100B blood level as a biomarker to avoid computed tomography in patients with mild head trauma under antithrombotic medication. Diagn Interv Imaging. 2017;98(7):551-556doi: 10.1016/j.diii.2017.03.010.
David, A., Mari, C., Vignaud, F., Masson, D., Planche, L., Bord, E., Bourcier, R., Frampas, E., Batard, E., & Desal, H. (2017). Evaluation of S100B blood level as a biomarker to avoid computed tomography in patients with mild head trauma under antithrombotic medication. Diagnostic and interventional imaging, 98(7), 551-556. https://doi.org/10.1016/j.diii.2017.03.010
David, A, et al. "Evaluation of S100B blood level as a biomarker to avoid computed tomography in patients with mild head trauma under antithrombotic medication." Diagnostic and interventional imaging vol. 98,7 (2017): 551-556. doi: https://doi.org/10.1016/j.diii.2017.03.010
David A, Mari C, Vignaud F, Masson D, Planche L, Bord E, Bourcier R, Frampas E, Batard E, Desal H. Evaluation of S100B blood level as a biomarker to avoid computed tomography in patients with mild head trauma under antithrombotic medication. Diagn Interv Imaging. 2017 Jul - Aug;98(7):551-556. doi: 10.1016/j.diii.2017.03.010. Epub 2017 Jun 01. PMID: 28579521.
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Diagn Interv Imaging. 2017 Jul - Aug;98(7):551-556. doi: 10.1016/j.diii.2017.03.010. Epub 2017 Jun 01.

Evaluation of S100B blood level as a biomarker to avoid computed tomography in patients with mild head trauma under antithrombotic medication.

Diagnostic and interventional imaging

A David, C Mari, F Vignaud, D Masson, L Planche, E Bord, R Bourcier, E Frampas, E Batard, H Desal

Affiliations

  1. Department of Neuroradiology, Centre Hospitalier Universitaire de Nantes, Boulevard Professeur-Jacques-Monod, 44800 Saint-Herblain, France. Electronic address: [email protected].
  2. Emergency Department, Centre Hospitalier de Saint-Nazaire, 11, Boulevard Georges-Charpak, 44600 Saint-Nazaire, France. Electronic address: [email protected].
  3. Emergency Department, Centre Hospitalier Universitaire de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. Electronic address: [email protected].
  4. Service de Biochimie, Centre Hospitalier Universitaire de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. Electronic address: [email protected].
  5. Plateforme de Biométrie, Centre Hospitalier Universitaire de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. Electronic address: [email protected].
  6. Service de Neurotraumatologie, Centre Hospitalier Universitaire de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. Electronic address: [email protected].
  7. Service de Neuroradiologie diagnostique et interventionnelle, Centre Hospitalier Universitaire de Nantes, Boulevard Professeur-Jacques-Monod, 44800 Saint-Herblain, France. Electronic address: [email protected].
  8. Service de Radiologie centrale, Centre Hospitalier Universitaire de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. Electronic address: [email protected].
  9. Emergency Department, Centre Hospitalier Universitaire de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. Electronic address: [email protected].
  10. Service de Neuroradiologie diagnostique et interventionnelle, Centre Hospitalier Universitaire de Nantes, Boulevard Professeur-Jacques-Monod, 44800 Saint-Herblain, France. Electronic address: [email protected].

PMID: 28579521 DOI: 10.1016/j.diii.2017.03.010

Abstract

PURPOSE: The goal of this prospective study was to analyze the potential of S100B protein as a negative predictive marker for intracranial hemorrhage (ICH) after mild head trauma (MHT) in patient under antithrombotic medication.

METHODS: Patients under antithrombotic medication who had MHT were consecutively included in this study. S100B blood levels were determined from samples drawn within 6hours after injury and were analyzed with the results of head CT performed within the 24hours after injury. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of S100B levels for the detection of ICH, with a cut-off set at 0.105μg/L, were calculated.

RESULTS: A total of 308 patients (151 men and 157 women) with a mean age of 79.1±10.5years (SD) were included in the analysis. CT was positive for the presence of ICH in 33 patients (10.7%; 95% CI: 7.5-14.7%). In the study population, S100B showed a sensitivity of 84.8% (95%CI: 68.1-94.9%), a specificity of 30.2% (95% CI: 24.8-36.0%), a NPV of 94.3% (95% CI: 87.2-98.1%), and a PPV of 12.7% (95% CI: 8.6-17.9%) for the diagnosis of ICH.

CONCLUSION: The results of this study suggest that a S100B serum level<0.105μg/L has a high NPV for ICH after mild head trauma in patients under antithrombotic medication.

Copyright © 2017 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.

Keywords: Antithrombotic medication; Computed tomography; Intracranial hemorrhage; Mild head trauma; S100B protein

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