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Spichal M, Fabre E. The Emerging Role of the Cytoskeleton in Chromosome Dynamics. Front Genet. 2017;8:60doi: 10.3389/fgene.2017.00060.
Spichal, M., & Fabre, E. (2017). The Emerging Role of the Cytoskeleton in Chromosome Dynamics. Frontiers in genetics, 860. https://doi.org/10.3389/fgene.2017.00060
Spichal, Maya, and Fabre, Emmanuelle. "The Emerging Role of the Cytoskeleton in Chromosome Dynamics." Frontiers in genetics vol. 8 (2017): 60. doi: https://doi.org/10.3389/fgene.2017.00060
Spichal M, Fabre E. The Emerging Role of the Cytoskeleton in Chromosome Dynamics. Front Genet. 2017 May 19;8:60. doi: 10.3389/fgene.2017.00060. eCollection 2017. PMID: 28580009; PMCID: PMC5437106.
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Front Genet. 2017 May 19;8:60. doi: 10.3389/fgene.2017.00060. eCollection 2017.

The Emerging Role of the Cytoskeleton in Chromosome Dynamics.

Frontiers in genetics

Maya Spichal, Emmanuelle Fabre

Affiliations

  1. Department of Genetics, University of North Carolina, Chapel HillNC, United States.
  2. Equipe Biologie et Dynamique des Chromosomes, Institut Universitaire d'Hématologie, CNRS UMR 7212, INSERM U944, Hôpital St. Louis 1Paris, France.

PMID: 28580009 PMCID: PMC5437106 DOI: 10.3389/fgene.2017.00060

Abstract

Chromosomes underlie a dynamic organization that fulfills functional roles in processes like transcription, DNA repair, nuclear envelope stability, and cell division. Chromosome dynamics depend on chromosome structure and cannot freely diffuse. Furthermore, chromosomes interact closely with their surrounding nuclear environment, which further constrains chromosome dynamics. Recently, several studies enlighten that cytoskeletal proteins regulate dynamic chromosome organization. Cytoskeletal polymers that include actin filaments, microtubules and intermediate filaments can connect to the nuclear envelope via Linker of the Nucleoskeleton and Cytoskeleton (LINC) complexes and transfer forces onto chromosomes inside the nucleus. Monomers of these cytoplasmic polymers and related proteins can also enter the nucleus and play different roles in the interior of the nucleus than they do in the cytoplasm. Nuclear cytoskeletal proteins can act as chromatin remodelers alone or in complexes with other nuclear proteins. They can also act as transcription factors. Many of these mechanisms have been conserved during evolution, indicating that the cytoskeletal regulation of chromosome dynamics is an essential process. In this review, we discuss the different influences of cytoskeletal proteins on chromosome dynamics by focusing on the well-studied model organism budding yeast.

Keywords: chromosomes; cytoskeleton; dynamics; nucleus; yeast

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