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Nie J, DuBois DC, Xue B, et al. Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats. Gene Regul Syst Bio. 2017;11:1177625017710009doi: 10.1177/1177625017710009.
Nie, J., DuBois, D. C., Xue, B., Jusko, W. J., & Almon, R. R. (2017). Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats. Gene regulation and systems biology, 111177625017710009. https://doi.org/10.1177/1177625017710009
Nie, Jing, et al. "Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats." Gene regulation and systems biology vol. 11 (2017): 1177625017710009. doi: https://doi.org/10.1177/1177625017710009
Nie J, DuBois DC, Xue B, Jusko WJ, Almon RR. Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats. Gene Regul Syst Bio. 2017 May 29;11:1177625017710009. doi: 10.1177/1177625017710009. eCollection 2017. PMID: 28607540; PMCID: PMC5457139.
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Gene Regul Syst Bio. 2017 May 29;11:1177625017710009. doi: 10.1177/1177625017710009. eCollection 2017.

Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats.

Gene regulation and systems biology

Jing Nie, Debra C DuBois, Bai Xue, William J Jusko, Richard R Almon

Affiliations

  1. Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
  2. Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.

PMID: 28607540 PMCID: PMC5457139 DOI: 10.1177/1177625017710009

Abstract

In the present report, we examined the responses of diabetic Goto-Kakizaki (GK) rats and control Wistar-Kyoto (WKY) rats fed either a standard chow or high-fat diet (HFD) from weaning to 20 weeks of age. This comparison included gene expression profiling of skeletal muscle using Affymetrix gene array chips. The expression profiling is interpreted within the context of a wide array of physiological measurements. Genes whose expressions are different between the 2 strains regardless of diet, as well as genes that differ between strains only with HFD, were identified. In addition, genes that were regulated by diet in 1 or both strains were identified. The results suggest that both strains respond to HFD by an increased capacity to oxidize lipid fuels in the musculature but that this adaptation occurs more rapidly in WKY rats. The results also demonstrated an impaired cytokine signalling and heightened inflammatory status in the GK rats.

Keywords: Diabetes; gene expression; high-fat diet; microarrays; skeletal muscle

Conflict of interest statement

DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Disclosures and Ethics As

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