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Scheri GC, Fard SN, Schietroma I, et al. Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus-Positive Patients: Preliminary Results of a New Study Approach. Int J Tryptophan Res. 2017;10:1178646917710668doi: 10.1177/1178646917710668.
Scheri, G. C., Fard, S. N., Schietroma, I., Mastrangelo, A., Pinacchio, C., Giustini, N., Serafino, S., De Girolamo, G., Cavallari, E. N., Statzu, M., Laghi, L., Vullo, A., Ceccarelli, G., Vullo, V., & d'Ettorre, G. (2017). Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus-Positive Patients: Preliminary Results of a New Study Approach. International journal of tryptophan research : IJTR, 101178646917710668. https://doi.org/10.1177/1178646917710668
Scheri, Giuseppe Corano, et al. "Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus-Positive Patients: Preliminary Results of a New Study Approach." International journal of tryptophan research : IJTR vol. 10 (2017): 1178646917710668. doi: https://doi.org/10.1177/1178646917710668
Scheri GC, Fard SN, Schietroma I, Mastrangelo A, Pinacchio C, Giustini N, Serafino S, De Girolamo G, Cavallari EN, Statzu M, Laghi L, Vullo A, Ceccarelli G, Vullo V, d'Ettorre G. Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus-Positive Patients: Preliminary Results of a New Study Approach. Int J Tryptophan Res. 2017 May 30;10:1178646917710668. doi: 10.1177/1178646917710668. eCollection 2017. PMID: 28607543; PMCID: PMC5457170.
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Int J Tryptophan Res. 2017 May 30;10:1178646917710668. doi: 10.1177/1178646917710668. eCollection 2017.

Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus-Positive Patients: Preliminary Results of a New Study Approach.

International journal of tryptophan research : IJTR

Giuseppe Corano Scheri, Saeid Najafi Fard, Ivan Schietroma, Andrea Mastrangelo, Claudia Pinacchio, Noemi Giustini, Sara Serafino, Gabriella De Girolamo, Eugenio Nelson Cavallari, Maura Statzu, Luca Laghi, Annamaria Vullo, Giancarlo Ceccarelli, Vincenzo Vullo, Gabriella d'Ettorre

Affiliations

  1. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  2. Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  3. Department of Agro-Food Science and Technology, University of Bologna, Bologna, Italy.
  4. Department of Anatomical, Histological, Forensic and Orthopaedic Sciences,Sapienza University of Rome, Rome, Italy.
  5. Department of Public Health and Infectious Diseases, Azienda Policlinico Umberto I, Rome, Italy.

PMID: 28607543 PMCID: PMC5457170 DOI: 10.1177/1178646917710668

Abstract

BACKGROUND: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1-infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of this study was to investigate the link between probiotic supplementation and serotonin levels in combined antiretroviral therapy-treated patients and the subsistence of an interplay with inflammation.

METHODS: We conducted a pilot study that included 8 HIV-positive subjects. We collected blood and fecal samples before and after 6 months of probiotic supplementation, to measure the level of serotonin in serum and tryptophan in stool, the expression of CD38 and HLA-DR on peripheral CD4+ T lymphocytes (as immune activation markers), the expression of indoleamine 2,3-dioxygenase 1 messenger RNA (mRNA) and IFN-γ mRNA (as markers of tryptophan metabolism and systemic inflammation).

RESULTS: After probiotic supplementation, we observed a significant increase in concentration of serum serotonin (

CONCLUSIONS: Considering that this probiotic (Vivomixx® in EU; Visbiome® in USA) has an influence on tryptophan metabolism, larger studies on this topic are needed.

Keywords: HIV; IDO-1; IFN-γ; Probiotics; serotonin; tryptophan

Conflict of interest statement

DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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