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Lv Y, Xiao J, Liu J, et al. E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma. J Cancer. 2017;8(7):1205-1213doi: 10.7150/jca.18255.
Lv, Y., Xiao, J., Liu, J., & Xing, F. (2017). E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma. Journal of Cancer, 8(7), 1205-1213. https://doi.org/10.7150/jca.18255
Lv, Yi, et al. "E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma." Journal of Cancer vol. 8,7 (2017): 1205-1213. doi: https://doi.org/10.7150/jca.18255
Lv Y, Xiao J, Liu J, Xing F. E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma. J Cancer. 2017 Apr 09;8(7):1205-1213. doi: 10.7150/jca.18255. eCollection 2017. PMID: 28607595; PMCID: PMC5463435.
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J Cancer. 2017 Apr 09;8(7):1205-1213. doi: 10.7150/jca.18255. eCollection 2017.

E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma.

Journal of Cancer

Yi Lv, Jia Xiao, Jing Liu, Feiyue Xing

Affiliations

  1. Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China.
  2. Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China.
  3. Department of Stomatology, Jinan University, Guangzhou, China.

PMID: 28607595 PMCID: PMC5463435 DOI: 10.7150/jca.18255

Abstract

E2F transcriptional factors are widely expressed in a number of tissues and organs, possessing many regulatory functions related to cellular proliferation, differentiation, DNA repair, cell-cycle and cell apoptosis. E2F8 is a recently identified member of the E2F family with a duplicated DNA-binding domain feature discriminated from E2F1-6, controlling gene expression in a dimerization partner-independent manner. It is indispensable for angiogenesis, lymphangiogenesis and embryonic development. Although E2F8 and E2F7 perform complementary and overlapping functions in many cell metabolisms, E2F8, but not E2F7, overexpresses remarkably in hepatocellular carcinoma (HCC) to facilitate the HCC occurrence and development

Keywords: DNA damage.; E2F8; Hepatocellular carcinoma; angiogenesis; lymphangiogenesis; polyploidization

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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