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Koffas A, Murray-Lyon IM, Williams R. Azithromycin-induced cholestatic hepatitis. Oxf Med Case Reports. 2017;2017(6):omx027doi: 10.1093/omcr/omx027.
Koffas, A., Murray-Lyon, I. M., & Williams, R. (2017). Azithromycin-induced cholestatic hepatitis. Oxford medical case reports, 2017(6), omx027. https://doi.org/10.1093/omcr/omx027
Koffas, Apostolos, et al. "Azithromycin-induced cholestatic hepatitis." Oxford medical case reports vol. 2017,6 (2017): omx027. doi: https://doi.org/10.1093/omcr/omx027
Koffas A, Murray-Lyon IM, Williams R. Azithromycin-induced cholestatic hepatitis. Oxf Med Case Reports. 2017 Jun 01;2017(6):omx027. doi: 10.1093/omcr/omx027. eCollection 2017 Jun. PMID: 28580159; PMCID: PMC5451892.
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Oxf Med Case Reports. 2017 Jun 01;2017(6):omx027. doi: 10.1093/omcr/omx027. eCollection 2017 Jun.

Azithromycin-induced cholestatic hepatitis.

Oxford medical case reports

Apostolos Koffas, Iain M Murray-Lyon, Roger Williams

Affiliations

  1. The Liver Centre, The London Clinic, London, UK.
  2. Institute of Hepatology, Foundation for Liver Research, London, UK.

PMID: 28580159 PMCID: PMC5451892 DOI: 10.1093/omcr/omx027

Abstract

Since its introduction >20 years ago, Azithromycin has been widely used owing to its broad spectrum and good tolerability, especially when used for <7 days. In literature, there are only very few, sporadic reports available of patients developing cholestatic hepatitis following treatment with it. The current case study describes a 69-year old patient, with a medical history that included significant alcohol consumption, who presented with jaundice following a 3-day course of Azithromycin. Following a transjugular liver biopsy, he was managed with a short course of corticosteroids and his liver function gradually improved and finally normalized ~2 months after discontinuation of Azithromycin.

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