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Mehta RS, Dave H, Bollard CM, et al. Engineering cord blood to improve engraftment after cord blood transplant. Stem Cell Investig. 2017;4:41doi: 10.21037/sci.2017.05.01.
Mehta, R. S., Dave, H., Bollard, C. M., & Shpall, E. J. (2017). Engineering cord blood to improve engraftment after cord blood transplant. Stem cell investigation, 441. https://doi.org/10.21037/sci.2017.05.01
Mehta, Rohtesh S, et al. "Engineering cord blood to improve engraftment after cord blood transplant." Stem cell investigation vol. 4 (2017): 41. doi: https://doi.org/10.21037/sci.2017.05.01
Mehta RS, Dave H, Bollard CM, Shpall EJ. Engineering cord blood to improve engraftment after cord blood transplant. Stem Cell Investig. 2017 May 25;4:41. doi: 10.21037/sci.2017.05.01. eCollection 2017. PMID: 28607915; PMCID: PMC5460100.
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Stem Cell Investig. 2017 May 25;4:41. doi: 10.21037/sci.2017.05.01. eCollection 2017.

Engineering cord blood to improve engraftment after cord blood transplant.

Stem cell investigation

Rohtesh S Mehta, Hema Dave, Catherine M Bollard, Elizabeth J Shpall

Affiliations

  1. Department of Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX, USA.
  2. Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System, Washington DC, USA.
  3. Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington DC, USA.

PMID: 28607915 PMCID: PMC5460100 DOI: 10.21037/sci.2017.05.01

Abstract

Umbilical cord blood transplant (CBT) has traditionally been associated with slower engraftment of neutrophils, delayed immune reconstitution and consequently higher risk of infections as compared with peripheral blood progenitor cell (PBPC) or bone marrow (BM) transplants. This is primarily due to low numbers of total nucleated cells (TNCs) and the naive nature of CB immune cells. The use of double unit CB transplant (DCBT) increases the total cell dose in the graft, but it still does not produce as rapid engraftment as seen with PBPC or even BM transplants. Herein, we discuss strategies to improve engraftment after CBT. We describe methods of (I) expansion of CB graft

Keywords: Cord blood transplant (CBT); T cells; engraftment; graft manipulation

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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