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Nikuei P, Rajaei M, Malekzadeh K, et al. Expression of placental growth factor mRNA in preeclampsia. Int J Reprod Biomed. 2017;15(3):169-174
Nikuei, P., Rajaei, M., Malekzadeh, K., Nejatizadeh, A., Mohseni, F., Poordarvishi, F., Ghashghaeezadeh, N., & Mohtarami, M. (2017). Expression of placental growth factor mRNA in preeclampsia. International journal of reproductive biomedicine, 15(3), 169-174.
Nikuei, Pooneh, et al. "Expression of placental growth factor mRNA in preeclampsia." International journal of reproductive biomedicine vol. 15,3 (2017): 169-174.
Nikuei P, Rajaei M, Malekzadeh K, Nejatizadeh A, Mohseni F, Poordarvishi F, Ghashghaeezadeh N, Mohtarami M. Expression of placental growth factor mRNA in preeclampsia. Int J Reprod Biomed. 2017 Mar;15(3):169-174. PMID: 28580450; PMCID: PMC5447834.
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Int J Reprod Biomed. 2017 Mar;15(3):169-174.

Expression of placental growth factor mRNA in preeclampsia.

International journal of reproductive biomedicine

Pooneh Nikuei, Minoo Rajaei, Kianoosh Malekzadeh, Azim Nejatizadeh, Fatemeh Mohseni, Fatemeh Poordarvishi, Nasrin Ghashghaeezadeh, Mehrdad Mohtarami

Affiliations

  1. Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  2. Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  3. Department of Medical Genetics; Faculty of Medicine; Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  4. Biology Department, Long Island University, Post Campus, New York, USA.

PMID: 28580450 PMCID: PMC5447834

Abstract

BACKGROUND: Preeclampsia (PE) is a serious complication of pregnancy with hallmarks of incomplete placentation, placental ischemia and endothelial dysfunction. Imbalance between vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors play important role in pathophysiology of PE.

OBJECTIVE: This study was aimed to asses PlGF mRNA expression in placenta of women affected with PE.

MATERIAL AND METHODS: In this cross-sectional study, expression of PlGF mRNA was evaluated in 26 mild PE cases, 15 severe preeclamptic women and 20 normotensive controls. Patients were sub-classified as early onset PE (9) and late onset (32). After RNA extraction, PlGF expression was quantified with qRT-PCR.

RESULTS: The results of PlGF mRNA expression between mild-severe, and early-late onset PE patients showed no statistically significant difference compared with the control group (p=0.661, p=0.205 respectively).

CONCLUSION: Despite we found no distinct differential expression of PlGF mRNA in placental tissue of PE patients compared with control women, but according to decreased level of this angiogenic factor in PE even before clinical onset of the disease, determining molecular mechanisms related to reduced secretion of PlGF into the maternal circulation may be useful for future therapeutics.

Keywords: Endothelial dysfunction; Expression; Placental growth factor; Preeclampsia

Conflict of interest statement

The authors report no conflicts of interest.

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