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Maier KL, McKinstry-Wu AR, Palanca BJA, et al. Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study. Front Hum Neurosci. 2017;11:284doi: 10.3389/fnhum.2017.00284.
Maier, K. L., McKinstry-Wu, A. R., Palanca, B. J. A., Tarnal, V., Blain-Moraes, S., Basner, M., Avidan, M. S., Mashour, G. A., & Kelz, M. B. (2017). Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study. Frontiers in human neuroscience, 11284. https://doi.org/10.3389/fnhum.2017.00284
Maier, Kaitlyn L, et al. "Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study." Frontiers in human neuroscience vol. 11 (2017): 284. doi: https://doi.org/10.3389/fnhum.2017.00284
Maier KL, McKinstry-Wu AR, Palanca BJA, Tarnal V, Blain-Moraes S, Basner M, Avidan MS, Mashour GA, Kelz MB. Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study. Front Hum Neurosci. 2017 Jun 07;11:284. doi: 10.3389/fnhum.2017.00284. eCollection 2017. PMID: 28638328; PMCID: PMC5461274.
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Front Hum Neurosci. 2017 Jun 07;11:284. doi: 10.3389/fnhum.2017.00284. eCollection 2017.

Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study.

Frontiers in human neuroscience

Kaitlyn L Maier, Andrew R McKinstry-Wu, Ben Julian A Palanca, Vijay Tarnal, Stefanie Blain-Moraes, Mathias Basner, Michael S Avidan, George A Mashour, Max B Kelz

Affiliations

  1. Department of Pharmacology, Perelman School of Medicine, University of PennsylvaniaPhiladelphia, PA, United States.
  2. Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of PennsylvaniaPhiladelphia, PA, United States.
  3. Department of Anesthesiology, Washington University School of Medicine, Washington University in St. LouisSt. Louis, MO, United States.
  4. Department of Anesthesiology, University of MichiganAnn Arbor, MI, United States.
  5. School of Physical and Occupational Therapy, McGill UniversityMontreal, QC, Canada.
  6. Department of Psychiatry, Perelman School of Medicine, University of PennsylvaniaPhiladelphia, PA, United States.
  7. Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of PennsylvaniaPhiladelphia, PA, United States.

PMID: 28638328 PMCID: PMC5461274 DOI: 10.3389/fnhum.2017.00284

Abstract

Important scientific and clinical questions persist about general anesthesia despite the ubiquitous clinical use of anesthetic drugs in humans since their discovery. For example, it is not known how the brain reconstitutes consciousness and cognition after the profound functional perturbation of the anesthetized state, nor has a specific pattern of functional recovery been characterized. To date, there has been a lack of detailed investigation into rates of recovery and the potential orderly return of attention, sensorimotor function, memory, reasoning and logic, abstract thinking, and processing speed. Moreover, whether such neurobehavioral functions display an invariant sequence of return across individuals is similarly unknown. To address these questions, we designed a study of healthy volunteers undergoing general anesthesia with electroencephalography and serial testing of cognitive functions (NCT01911195). The aims of this study are to characterize the temporal patterns of neurobehavioral recovery over the first several hours following termination of a deep inhaled isoflurane general anesthetic and to identify common patterns of cognitive function recovery. Additionally, we will conduct spectral analysis and reconstruct functional networks from electroencephalographic data to identify any neural correlates (e.g., connectivity patterns, graph-theoretical variables) of cognitive recovery after the perturbation of general anesthesia. To accomplish these objectives, we will enroll a total of 60 consenting adults aged 20-40 across the three participating sites. Half of the study subjects will receive general anesthesia slowly titrated to loss of consciousness (LOC) with an intravenous infusion of propofol and thereafter be maintained for 3 h with 1.3 age adjusted minimum alveolar concentration of isoflurane, while the other half of subjects serves as awake controls to gauge effects of repeated neurobehavioral testing, spontaneous fatigue and endogenous rest-activity patterns.

Keywords: cognition; consciousness; emergence; isoflurane anesthesia; neurobehavioral; sleep

References

  1. Curr Biol. 2012 Nov 6;22(21):2008-16 - PubMed
  2. Anesthesiology. 2011 Apr;114(4):872-81 - PubMed
  3. Anesthesiology. 2013 Jun;118(6):1264-75 - PubMed
  4. PLoS One. 2014 Jan 27;9(1):e87498 - PubMed
  5. Sleep. 2010 Jan;33(1):47-57 - PubMed
  6. Lancet. 2015 Apr 27;385 Suppl 2:S11 - PubMed
  7. Clin Pharmacol Ther. 2009 Jan;85(1):51-5 - PubMed
  8. Anesth Analg. 2006 Oct;103(4):975-82 - PubMed
  9. PLoS One. 2010 Jul 30;5(7):e11903 - PubMed
  10. Hum Brain Mapp. 2007 Nov;28(11):1178-93 - PubMed
  11. Aerosp Med Hum Perform. 2015 Nov;86(11):942-52 - PubMed
  12. Neuropsychologia. 1995 Aug;33(8):1027-46 - PubMed
  13. Best Pract Res Clin Anaesthesiol. 2007 Sep;21(3):313-25 - PubMed
  14. Br J Anaesth. 2003 Aug;91(2):170-4 - PubMed
  15. Neuropsychopharmacology. 2001 Nov;25(5):766-76 - PubMed
  16. Anesth Analg. 1998 Feb;86(2):414-21 - PubMed
  17. Anesthesiology. 1997 Sep;87(3):517-26 - PubMed
  18. Anesthesiology. 2014 Nov;121(5):990-8 - PubMed
  19. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1142-51 - PubMed
  20. Acta Astronaut. 2011 Dec 1;69(11-12):949-959 - PubMed
  21. Science. 2008 Nov 7;322(5903):876-80 - PubMed
  22. Neuropsychology. 2002 Jul;16(3):370-9 - PubMed
  23. Biol Psychiatry. 2000 Jan 1;47(1):34-42 - PubMed
  24. Comput Intell Neurosci. 2011;2011:879716 - PubMed
  25. Sleep. 2011 May 01;34(5):581-91 - PubMed
  26. Anesth Analg. 1970 Jul-Aug;49(4):564-6 - PubMed
  27. Neuron. 2011 Apr 28;70(2):200-27 - PubMed
  28. Sleep. 2005 Sep;28(9):1059-68 - PubMed
  29. Neuroimage. 2010 Sep;52(3):1059-69 - PubMed
  30. Anesthesiology. 1990 Jul;73(1):52-61 - PubMed
  31. Anesthesiology. 2013 Nov;119(5):1031-42 - PubMed
  32. J Neurosci Methods. 2010 Mar 30;187(2):254-62 - PubMed
  33. PLoS Comput Biol. 2014 Oct 16;10(10):e1003887 - PubMed
  34. Rev Bras Psiquiatr. 2014 Sep;36(3):248-50 - PubMed
  35. Nat Rev Neurosci. 2008 May;9(5):370-86 - PubMed
  36. PLoS One. 2014 Sep 29;9(9):e106291 - PubMed
  37. J Neurosci. 2015 Jul 29;35(30):10866-77 - PubMed
  38. Clin Sports Med. 2005 Apr;24(2):237-49, vii-viii - PubMed
  39. Phys Rev Lett. 2001 Nov 5;87(19):198701 - PubMed
  40. Anesthesiology. 1988 Sep;69(3):327-31 - PubMed
  41. Sleep. 1992 Oct;15(5):461-9 - PubMed
  42. J Neurosci. 2012 Apr 4;32(14):4935-43 - PubMed
  43. Nature. 1998 Jun 4;393(6684):440-2 - PubMed
  44. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8577-82 - PubMed
  45. Anesth Analg. 2016 Jan;122(1):234-42 - PubMed
  46. Anesth Analg. 2001 Dec;93(6):1489-94, table of contents - PubMed
  47. Neuroimage. 2004 Jan;21(1):456-62 - PubMed
  48. Anesthesiology. 2012 Jul;117(1):48-55 - PubMed
  49. Br J Anaesth. 1992 Sep;69(3):255-8 - PubMed
  50. Neuropsychology. 1997 Oct;11(4):602-12 - PubMed
  51. J Sleep Res. 2009 Jun;18(2):264-71 - PubMed
  52. PLoS Genet. 2013;9(9):e1003605 - PubMed
  53. Anesthesiology. 2016 Nov;125(5):861-872 - PubMed
  54. Neurosci Lett. 2009 Sep 29;463(1):1-5 - PubMed
  55. Sleep. 2003 Mar 15;26(2):117-26 - PubMed

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