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Apalla Z, Papageorgiou C, Lallas A, et al. Spotlight on vismodegib in the treatment of basal cell carcinoma: an evidence-based review of its place in therapy. Clin Cosmet Investig Dermatol. 2017;10:171-177doi: 10.2147/CCID.S101330.
Apalla, Z., Papageorgiou, C., Lallas, A., Sotiriou, E., Lazaridou, E., Vakirlis, E., Kyrgidis, A., & Ioannides, D. (2017). Spotlight on vismodegib in the treatment of basal cell carcinoma: an evidence-based review of its place in therapy. Clinical, cosmetic and investigational dermatology, 10171-177. https://doi.org/10.2147/CCID.S101330
Apalla, Zoe, et al. "Spotlight on vismodegib in the treatment of basal cell carcinoma: an evidence-based review of its place in therapy." Clinical, cosmetic and investigational dermatology vol. 10 (2017): 171-177. doi: https://doi.org/10.2147/CCID.S101330
Apalla Z, Papageorgiou C, Lallas A, Sotiriou E, Lazaridou E, Vakirlis E, Kyrgidis A, Ioannides D. Spotlight on vismodegib in the treatment of basal cell carcinoma: an evidence-based review of its place in therapy. Clin Cosmet Investig Dermatol. 2017 May 10;10:171-177. doi: 10.2147/CCID.S101330. eCollection 2017. PMID: 28546761; PMCID: PMC5436682.
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Clin Cosmet Investig Dermatol. 2017 May 10;10:171-177. doi: 10.2147/CCID.S101330. eCollection 2017.

Spotlight on vismodegib in the treatment of basal cell carcinoma: an evidence-based review of its place in therapy.

Clinical, cosmetic and investigational dermatology

Zoe Apalla, Chrysoula Papageorgiou, Aimilios Lallas, Elena Sotiriou, Elizabeth Lazaridou, Efstratios Vakirlis, Athanassios Kyrgidis, Demetrios Ioannides

Affiliations

  1. First Department of Dermatology, Aristotle University.
  2. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Aristotle University, Thessaloniki, Greece.

PMID: 28546761 PMCID: PMC5436682 DOI: 10.2147/CCID.S101330

Abstract

Vismodegib is approved for the treatment of adult patients with metastatic (mBCC) or locally advanced basal cell carcinoma (laBCC) that have recurred following surgery or for those who are not good candidates for surgery (risk/benefit ratio is against patient's benefit, either because of the general condition or because of the expected morbidity from the surgery) or radiation therapy. This article provides an evidence-based review of its current place in therapy. Analytically, the clinical implications in the management of laBCCs and mBCCs and possible new indications, including the neoadjuvant use before surgical excision, are discussed, while in the end, the challenges regarding class-related adverse events and their optimal management are highlighted.

Keywords: basal cell carcinoma; review; sonic hedgehog inhibitors; treatment; vismodegib

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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