Display options
Cite
Rabiee B, Roozafzai F, Hemasi GR, et al. The Prevalence of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus in an Iranian Population. Middle East J Dig Dis. 2017;9(2):86-93doi: 10.15171/mejdd.2017.56.
Rabiee, B., Roozafzai, F., Hemasi, G. R., Poustchi, H., Keyvani, H., Khonsari, M. R., Ajdarkosh, H., Maadi, M., Sima Saeedian, F., & Zamani, F. (2017). The Prevalence of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus in an Iranian Population. Middle East journal of digestive diseases, 9(2), 86-93. https://doi.org/10.15171/mejdd.2017.56
Rabiee, Behnam, et al. "The Prevalence of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus in an Iranian Population." Middle East journal of digestive diseases vol. 9,2 (2017): 86-93. doi: https://doi.org/10.15171/mejdd.2017.56
Rabiee B, Roozafzai F, Hemasi GR, Poustchi H, Keyvani H, Khonsari MR, Ajdarkosh H, Maadi M, Sima Saeedian F, Zamani F. The Prevalence of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus in an Iranian Population. Middle East J Dig Dis. 2017 Apr;9(2):86-93. doi: 10.15171/mejdd.2017.56. PMID: 28638584; PMCID: PMC5471107.
Copy Download .nbib Format: NLM
Share it on

Middle East J Dig Dis. 2017 Apr;9(2):86-93. doi: 10.15171/mejdd.2017.56.

The Prevalence of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus in an Iranian Population.

Middle East journal of digestive diseases

Behnam Rabiee, Farzin Roozafzai, Gholam Reza Hemasi, Hossein Poustchi, Hossein Keyvani, Mahmood Reza Khonsari, Hossein Ajdarkosh, Mansooreh Maadi, Fatemeh Sima Saeedian, Farhad Zamani

Affiliations

  1. Gastrointestinal and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
  2. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  3. Department of Virology, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 28638584 PMCID: PMC5471107 DOI: 10.15171/mejdd.2017.56

Abstract

BACKGROUND Type II diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are important causes of morbidity and mortality worldwide. We aimed to estimate the prevalence of DM in the context of NAFLD. METHODS In this cross-sectional study, we studied 5052 participants, aged 18 years and older, of a baseline population-based cohort in northern Iran (N=6143). The prevalence of DM was estimated in individuals with and without NAFLD. The association between NAFLD and T2DM was evaluated using logistic regression with the adjustment of confounding effects of age, sex, body mass index, lipid profiles, and fasting insulin. RESULTS In men, the prevalence (95% confidence interval) of T2DM was 5.34% (4.35%-6.34%) and 15.06% (13.12%-17.00%) in individuals without and with NAFLD, respectively (p <0.001). In women without NAFLD, the prevalence was 8.27% (6.83%-9.71%) while in the presence of NAFLD, the prevalence was 27.21% (24.59%-29.83%), (p <0.001). In univariate analysis, the chance of having T2DM was 3.700 (3.130-4.380) times more in patients with NAFLD compared with subjects without NAFLD (p<0.001). This chance was reduced (Odds Ratio=1.976, 95% CI: 1.593-2.451, p <0.001) after removing the effects of other variables. CONCLUSION The prevalence of T2DM is increased in the context of NAFLD. This condition may be considered as an independent predictor of T2DM.

Keywords: Diabetes mellitus; Iran; Non-alcoholic fatty liver disease; Non-communicable disease; Prevalence

Conflict of interest statement

CONFLICT OF INTEREST: The authors declare no conflict of interest related to this work.

References

  1. Int J Cardiol. 2017 Feb 1;228:52-57 - PubMed
  2. Diabetes Care. 2009 Nov;32 Suppl 2:S164-7 - PubMed
  3. Arch Iran Med. 2016 Feb;19(2):110-5 - PubMed
  4. World J Gastroenterol. 2016 Mar 14;22(10 ):3023-30 - PubMed
  5. J Gastroenterol Hepatol. 2004 Aug;19(8):854-8 - PubMed
  6. Acta Med Iran. 2015 Oct;53(10):596-607 - PubMed
  7. Hepat Mon. 2016 Aug 14;16(9):e39575 - PubMed
  8. Nat Rev Gastroenterol Hepatol. 2013 May;10(5):307-18 - PubMed
  9. Hepatol Res. 2011 Jul;41(7):670-4 - PubMed
  10. Curr Med Res Opin. 2010 Sep;26(9):2183-91 - PubMed
  11. Gut. 2012 Mar;61(3):409-15 - PubMed
  12. Hepatology. 2009 Mar;49(3):1017-44 - PubMed
  13. Clin Gastroenterol Hepatol. 2008 Jul;6(7):828-31 - PubMed
  14. Hepatology. 2005 Nov;42(5):987-1000 - PubMed
  15. J Clin Endocrinol Metab. 2007 Sep;92 (9):3490-7 - PubMed
  16. Metab Syndr Relat Disord. 2016 Jun;14(5):249-53 - PubMed
  17. World J Gastroenterol. 2015 Aug 28;21(32):9607-13 - PubMed
  18. Hepatology. 2004 Dec;40(6):1387-95 - PubMed
  19. J Diabetes Complications. 2016 Mar;30(2):269-74 - PubMed
  20. Int J Obes Relat Metab Disord. 1998 Dec;22(12):1164-71 - PubMed
  21. Asian Pac J Cancer Prev. 2015 ;16(5):1789-94 - PubMed
  22. Arch Iran Med. 2014 Nov;17(11):750-4 - PubMed
  23. Arch Iran Med. 2014 Jul;17(7):477-82 - PubMed
  24. Diabetes Care. 2012 Apr;35(4):873-8 - PubMed
  25. East Mediterr Health J. 2009 May-Jun;15(3):591-9 - PubMed
  26. Diabetes Res Clin Pract. 2013 Nov;102(2):147-8 - PubMed
  27. Scand J Gastroenterol. 2007 Sep;42(9):1023-30 - PubMed
  28. QJM. 2012 May;105(5):425-32 - PubMed
  29. Int J Organ Transplant Med. 2016;7(3):149-160 - PubMed
  30. Gut. 2010 Oct;59(10):1303-7 - PubMed
  31. Lancet. 2011 Feb 12;377(9765):557-67 - PubMed
  32. Clin Res Hepatol Gastroenterol. 2017 Feb;41(1):31-38 - PubMed
  33. Aliment Pharmacol Ther. 2011 Aug;34(3):274-85 - PubMed
  34. J Hepatol. 2013 Mar;58(3):593-608 - PubMed
  35. JAMA. 2002 Oct 9;288(14):1723-7 - PubMed
  36. N Engl J Med. 2007 Jan 18;356(3):213-5 - PubMed
  37. J Gastroenterol Hepatol. 2002 Feb;17 Suppl:S186-90 - PubMed
  38. Gastroenterology. 2005 Jun;128(7):1898-906 - PubMed
  39. Hepatology. 2012 Jun;55(6):2005-23 - PubMed

Publication Types