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Fawzy RM, Hashaad NI, Mansour AI, et al. Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis. Eur J Rheumatol. 2017;4(2):93-97doi: 10.5152/eurjrheum.2017.160076.
Fawzy, R. M., Hashaad, N. I., Mansour, A. I., Rabipour, S., & Morrison, C. (2017). Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis. European journal of rheumatology, 4(2), 93-97. https://doi.org/10.5152/eurjrheum.2017.160076
Fawzy, Rasha Mohamed, et al. "Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis." European journal of rheumatology vol. 4,2 (2017): 93-97. doi: https://doi.org/10.5152/eurjrheum.2017.160076
Fawzy RM, Hashaad NI, Mansour AI, Rabipour S, Morrison C. Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis. Eur J Rheumatol. 2017 Jun;4(2):93-97. doi: 10.5152/eurjrheum.2017.160076. Epub 2017 Jun 01. PMID: 28638679; PMCID: PMC5473462.
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Eur J Rheumatol. 2017 Jun;4(2):93-97. doi: 10.5152/eurjrheum.2017.160076. Epub 2017 Jun 01.

Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis.

European journal of rheumatology

Rasha Mohamed Fawzy, Nashwa Ismail Hashaad, Amira Ibrahim Mansour, Rabipour, Morrison

Affiliations

  1. Department of Rheumatology, Rehabilitation & Physical Medicine, Benha University School of Medicine, Benha, Egypt.
  2. Department of Clinical and Chemical Pathology, Benha University School of Medicine, Benha, Egypt.

PMID: 28638679 PMCID: PMC5473462 DOI: 10.5152/eurjrheum.2017.160076

Abstract

OBJECTIVE: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional status of the osteoarthritic knee joint.

MATERIAL AND METHODS: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group I): including patients with KL grade < 3 and (Group II): including patients with KL grade ≥3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was prepared and injected immediately into the affected knee. Serum Coll2-1 (S.Coll2-1) concentration was measured by enzyme-linked immunosorbent assay (ELISA) kit pre and 3 months after PRP injection.

RESULTS: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p<0.001) and (p<0.05) in group I and group II respectively as well as significant improvements in WOMAC total and WOMAC sub-scores values were noted after single intra-articular PRP injection with maximal functional improvements were achieved after 3 months (p<0.001). Mild cases experienced favorable results with no remarkable adverse reactions were observed.

CONCLUSION: Reduction in specific OA biomarker S.Coll2-1 following intra-articular PRP injection emphasize that PRP could be a promising safe and tolerable effective therapeutic option which improves function from basal states in primary knee OA patients.

Keywords: McMaster Universities Arthritis Index Score; Platelet-rich plasma; Western Ontario; growth factors; knee osteoarthritis; serum coll2-1

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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