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Corominas H, Tsokos M, Quezado M, et al. Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature. Eur J Rheumatol. 2017;4(2):133-135doi: 10.5152/eurjrheum.2017.17066.
Corominas, H., Tsokos, M., Quezado, M., & Tsokos, G. C. (2017). Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature. European journal of rheumatology, 4(2), 133-135. https://doi.org/10.5152/eurjrheum.2017.17066
Corominas, Hector, et al. "Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature." European journal of rheumatology vol. 4,2 (2017): 133-135. doi: https://doi.org/10.5152/eurjrheum.2017.17066
Corominas H, Tsokos M, Quezado M, Tsokos GC. Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature. Eur J Rheumatol. 2017 Jun;4(2):133-135. doi: 10.5152/eurjrheum.2017.17066. Epub 2017 Jun 01. PMID: 28638687; PMCID: PMC5473449.
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Eur J Rheumatol. 2017 Jun;4(2):133-135. doi: 10.5152/eurjrheum.2017.17066. Epub 2017 Jun 01.

Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature.

European journal of rheumatology

Hector Corominas, Maria Tsokos, Martha Quezado, George C Tsokos

Affiliations

  1. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
  2. Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.

PMID: 28638687 PMCID: PMC5473449 DOI: 10.5152/eurjrheum.2017.17066

Abstract

Cardiovascular manifestations in patients with systemic lupus erythematosus (SLE) are common, but aortic aneurysm formation is rare. We present a 63-year-old male SLE patient with a two-year history of skin lesions, leucopenia, pericarditis, mitral valve vegetations consistent with Liebman-Sacks endocarditis, and an aneurysm of the ascending aorta, which was successfully repaired surgically. Histologic examination of the aneurysm showed medial cystic degeneration, smooth muscle necrosis, and mild adventitial perivascular lymphocytic aggregates. This histology is typical of thoracic aneurysms that carry a high risk for aortic dissection and patient death. The case highlights the importance of early detection and treatment of thoracic aortic aneurysms in patients with SLE.

Keywords: Systemic lupus erythematosus; aortic aneurysm; inflammation

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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