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Oncoimmunology. 2017 Mar 20;6(5):e1306617. doi: 10.1080/2162402X.2017.1306617. eCollection 2017.

Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors.

Oncoimmunology

Keisuke Fujii, Yoshihiro Miyahara, Naozumi Harada, Daisuke Muraoka, Mitsuhiro Komura, Rui Yamaguchi, Hideo Yagita, Junko Nakamura, Sahoko Sugino, Satoshi Okumura, Seiya Imoto, Satoru Miyano, Hiroshi Shiku

Affiliations

  1. Department of Immuno-Gene Therapy, Graduate School of Medicine, Mie University, Mie, Japan.
  2. Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
  3. Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  4. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
  5. Division of Health Medical Data Science, Health Intelligence Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

PMID: 28638727 PMCID: PMC5467990 DOI: 10.1080/2162402X.2017.1306617

Abstract

The CXCR3 ligands CXCL9, 10, and 11 play critical roles in the amplification of immune responses by recruiting CXCR3

Keywords: CXCR3 ligands; Checkpoint blockade; immune response; mutated antigen; neo-epitope

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