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Interv Cardiol Clin. 2015 Jul;4(3):333-349. doi: 10.1016/j.iccl.2015.03.001. Epub 2015 May 29.

Short- and Long-term Evaluation of Bioresorbable Scaffolds by Optical Coherence Tomography.

Interventional cardiology clinics

Carlos M Campos, Pannipa Suwannasom, Shimpei Nakatani, Yoshinobu Onuma, Patrick W Serruys, Hector M Garcia-Garcia

Affiliations

  1. Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Centre, Dr. Molewaterplein 40, Rotterdam 3015 GD, The Netherlands; Department of Interventional Cardiology Heart Institute (InCor), University of São Paulo Medical School, Avenida Doutor Enéas de Carvalho Aguiar, 44 - Terceiro Andar, Sao Paulo 05403-900, Brazil.
  2. Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Centre, Dr. Molewaterplein 40, Rotterdam 3015 GD, The Netherlands.
  3. Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Centre, Dr. Molewaterplein 40, Rotterdam 3015 GD, The Netherlands; International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  4. Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Centre, Dr. Molewaterplein 40, Rotterdam 3015 GD, The Netherlands; Medical Affairs, Cardialysis, Westblaak 98, Entrance B, Rotterdam 3012 KM, The Netherlands. Electronic address: [email protected].

PMID: 28581949 DOI: 10.1016/j.iccl.2015.03.001

Abstract

The analysis of bioresorbable scaffolds (BRSs) by optical coherence tomography (OCT) requires a dedicated methodology, as the polymeric scaffold has a distinct appearance and undergoes dynamic structural changes with time. The high resolution of OCT allows for the detailed assessment of scaffold implantation, rupture, discontinuity, and strut integration. OCT does not provide reliable information on the extent of scaffold degradation, as it cannot differentiate between polylactide polymer and the provisional matrix of proteoglycan formed by connective tissue. Three-dimensional OCT reconstruction can aid in the evaluation of BRS in special scenarios such as overlapping scaffold segments and bifurcations.

Copyright © 2015 Elsevier Inc. All rights reserved.

Keywords: Bioresorbable scaffolds; Drug-eluting stents; Optical coherence tomography

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