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Gurbel PA, Tantry US. The Role of Platelet Function Testing in Risk Stratification and Clinical Decision-Making. Interv Cardiol Clin. 2013;2(4):607-614doi: 10.1016/j.iccl.2013.05.009.
Gurbel, P. A., & Tantry, U. S. (2013). The Role of Platelet Function Testing in Risk Stratification and Clinical Decision-Making. Interventional cardiology clinics, 2(4), 607-614. https://doi.org/10.1016/j.iccl.2013.05.009
Gurbel, Paul A, and Tantry, Udaya S. "The Role of Platelet Function Testing in Risk Stratification and Clinical Decision-Making." Interventional cardiology clinics vol. 2,4 (2013): 607-614. doi: https://doi.org/10.1016/j.iccl.2013.05.009
Gurbel PA, Tantry US. The Role of Platelet Function Testing in Risk Stratification and Clinical Decision-Making. Interv Cardiol Clin. 2013 Oct;2(4):607-614. doi: 10.1016/j.iccl.2013.05.009. Epub 2013 Jul 10. PMID: 28582187.
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Interv Cardiol Clin. 2013 Oct;2(4):607-614. doi: 10.1016/j.iccl.2013.05.009. Epub 2013 Jul 10.

The Role of Platelet Function Testing in Risk Stratification and Clinical Decision-Making.

Interventional cardiology clinics

Paul A Gurbel, Udaya S Tantry

Affiliations

  1. Cardiac Catheterization Laboratory, Sinai Center for Thrombosis Research, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA. Electronic address: [email protected].
  2. Cardiac Catheterization Laboratory, Sinai Center for Thrombosis Research, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA.

PMID: 28582187 DOI: 10.1016/j.iccl.2013.05.009

Abstract

Clopidogrel (a widely used second-generation thienopyridine) therapy is associated with an unpredictable pharmacodynamic response whereby approximately 1 in 3 patients will have a high on-treatment platelet reactivity to adenosine diphosphate. High on-treatment platelet reactivity is an established risk factor for ischemic event occurrence in patients undergoing percutaneous coronary intervention. Platelet function testing may have a role in monitoring therapeutic efficacy when clopidogrel is the chosen agent and in safety when more potent drugs are used, especially in patients with high bleeding risk. At this time, it seems most reasonable to assess platelet function in high-risk clopidogrel-treated patients.

Copyright © 2013 Elsevier Inc. All rights reserved.

Keywords: Bleeding; Clopidogrel; High on-treatment platelet reactivity; P2Y(12) receptor; Percutaneous coronary intervention; Platelet function testing

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