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Piccolo P, Brunetti-Pierri N. Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy. Biomedicines. 2014;2(2):132-148doi: 10.3390/biomedicines2020132.
Piccolo, P., & Brunetti-Pierri, N. (2014). Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy. Biomedicines, 2(2), 132-148. https://doi.org/10.3390/biomedicines2020132
Piccolo, Pasquale, and Brunetti-Pierri, Nicola. "Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy." Biomedicines vol. 2,2 (2014): 132-148. doi: https://doi.org/10.3390/biomedicines2020132
Piccolo P, Brunetti-Pierri N. Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy. Biomedicines. 2014 Apr 02;2(2):132-148. doi: 10.3390/biomedicines2020132. PMID: 28548064; PMCID: PMC5423471.
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Biomedicines. 2014 Apr 02;2(2):132-148. doi: 10.3390/biomedicines2020132.

Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy.

Biomedicines

Pasquale Piccolo, Nicola Brunetti-Pierri

Affiliations

  1. Telethon Institute of Genetics and Medicine, Naples 80131, Italy. [email protected].
  2. Telethon Institute of Genetics and Medicine, Naples 80131, Italy. [email protected].
  3. Department of Translational Medicine, Federico II University of Naples, Naples 80131, Italy. [email protected].

PMID: 28548064 PMCID: PMC5423471 DOI: 10.3390/biomedicines2020132

Abstract

Helper-dependent adenoviral (HDAd) vectors that are devoid of all viral coding sequences are promising non-integrating vectors for gene therapy because they efficiently transduce a variety of cell types

Keywords: adenovirus; gutless vectors; helper-dependent adenoviral vectors; liver directed gene therapy

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