Display options
Cite
Gupta A, Bopanna S, Kedia S, et al. Familial aggregation of inflammatory bowel disease in patients with ulcerative colitis. Intest Res. 2017;15(3):388-394doi: 10.5217/ir.2017.15.3.388.
Gupta, A., Bopanna, S., Kedia, S., Yadav, D. P., Goyal, S., Jain, S., Makharia, G., & Ahuja, V. (2017). Familial aggregation of inflammatory bowel disease in patients with ulcerative colitis. Intestinal research, 15(3), 388-394. https://doi.org/10.5217/ir.2017.15.3.388
Gupta, Akshita, et al. "Familial aggregation of inflammatory bowel disease in patients with ulcerative colitis." Intestinal research vol. 15,3 (2017): 388-394. doi: https://doi.org/10.5217/ir.2017.15.3.388
Gupta A, Bopanna S, Kedia S, Yadav DP, Goyal S, Jain S, Makharia G, Ahuja V. Familial aggregation of inflammatory bowel disease in patients with ulcerative colitis. Intest Res. 2017 Jul;15(3):388-394. doi: 10.5217/ir.2017.15.3.388. Epub 2017 Jun 12. PMID: 28670236; PMCID: PMC5478764.
Copy Download .nbib Format: NLM
Share it on

Intest Res. 2017 Jul;15(3):388-394. doi: 10.5217/ir.2017.15.3.388. Epub 2017 Jun 12.

Familial aggregation of inflammatory bowel disease in patients with ulcerative colitis.

Intestinal research

Akshita Gupta, Sawan Bopanna, Saurabh Kedia, Dawesh Prakash Yadav, Sandeep Goyal, Saransh Jain, Govind Makharia, Vineet Ahuja

Affiliations

  1. Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

PMID: 28670236 PMCID: PMC5478764 DOI: 10.5217/ir.2017.15.3.388

Abstract

BACKGROUND/AIMS: Familial occurrence of inflammatory bowel disease (IBD) is well documented. Reports from Western countries have shown a higher familial occurrence of ulcerative colitis (UC) in first- and second-degree relatives than that in the Asian UC population. No data are currently available from the Indian subcontinent in this regard. We present our data on the familial aggregation of UC.

METHODS: Records of patients with UC followed at the Inflammatory Bowel Disease Clinic at the All India Institute of Medical Sciences, New Delhi from August 2004 to January 2016 were reviewed. Details regarding the prevalence of family history and characteristics of these patients were recorded. Affected family members were contacted and disease characteristics were noted for assessment of familial aggregation.

RESULTS: Of the 2,058 UC patients included in the analysis, a positive family history of IBD was confirmed in 31 patients (1.5%), 24 (77.4%) of whom had only first-degree relatives affected. All the affected relatives had UC and none had Crohn's disease. Among first-degree relatives, siblings were found to have the highest prevalence of IBD (53.3%), followed by parents (26.7%).

CONCLUSIONS: The probability of occurrence of IBD in family members of affected North Indian UC patients is lower than that reported in Western populations.

Keywords: Colitis, ulcerative; Medical history taking

Conflict of interest statement

Conflict of interest: None.

References

  1. World J Gastroenterol. 2014 Dec 7;20(45):17120-6 - PubMed
  2. Lancet. 1996 May 4;347(9010):1212-7 - PubMed
  3. Gut. 2015 Apr;64(4):571-9 - PubMed
  4. Gut. 1996 May;38(5):738-41 - PubMed
  5. Inflamm Bowel Dis. 2006 Dec;12(12):1146-51 - PubMed
  6. Eur J Hum Genet. 2003 Jan;11(1):6-16 - PubMed
  7. Scand J Gastroenterol Suppl. 1997;223:88-91 - PubMed
  8. Indian J Gastroenterol. 2012 Dec;31(6):294-6 - PubMed
  9. Curr Gastroenterol Rep. 2008 Dec;10(6):568-75 - PubMed
  10. J Crohns Colitis. 2014 Mar;8(3):234-9 - PubMed
  11. Scand J Gastroenterol. 1987 Mar;22(2):214-8 - PubMed
  12. Int J Colorectal Dis. 2002 Jul;17(4):233-7 - PubMed
  13. Scand J Gastroenterol. 2000 Oct;35(10):1075-81 - PubMed
  14. Gastroenterology. 2002 Jul;123(1):86-91 - PubMed
  15. Nature. 2012 Nov 1;491(7422):119-24 - PubMed
  16. Inflamm Bowel Dis. 2016 Aug;22(8):1954-60 - PubMed
  17. Gut. 1985 Sep;26(9):952-4 - PubMed
  18. J Crohns Colitis. 2016 Sep;10 (9):1024-32 - PubMed
  19. Indian J Gastroenterol. 2012 Dec;31(6):299-306 - PubMed
  20. Brain. 1989 Jun;112 ( Pt 3):779-97 - PubMed
  21. J Dig Dis. 2010 Jun;11(3):134-47 - PubMed
  22. J Gastroenterol. 2012 Sep;47(9):961-8 - PubMed
  23. Nature. 2001 May 31;411(6837):603-6 - PubMed
  24. N Engl J Med. 1991 Jan 10;324(2):84-8 - PubMed
  25. Tissue Antigens. 1999 Apr;53(4 Pt 1):350-8 - PubMed
  26. Am J Gastroenterol. 2001 Oct;96(10):2939-45 - PubMed
  27. Clin Exp Immunol. 1997 Jun;108(3):392-5 - PubMed
  28. Gastroenterology. 1996 Sep;111(3):813-5 - PubMed
  29. Eur J Gastroenterol Hepatol. 2010 Jun;22(6):710-5 - PubMed
  30. Gut. 1988 Jul;29(7):990-6 - PubMed
  31. Nat Genet. 2015 Sep;47(9):979-86 - PubMed
  32. BMC Gastroenterol. 2010 Mar 19;10:32 - PubMed
  33. J Crohns Colitis. 2012 Dec;6(10):965-90 - PubMed
  34. Dig Dis Sci. 1995 Apr;40(4):814-8 - PubMed
  35. World J Gastroenterol. 2006 Aug 14;12(30):4807-12 - PubMed
  36. Am J Gastroenterol. 2007 Sep;102(9):1955-63 - PubMed
  37. Gastroenterology. 2016 Jan;150(1):86-95.e3; quiz e13-4 - PubMed
  38. Nature. 2001 May 31;411(6837):599-603 - PubMed
  39. Gut. 1993 Apr;34(4):517-24 - PubMed
  40. Gastroenterology. 1989 Apr;96(4):1016-20 - PubMed
  41. World J Gastroenterol. 2002 Feb;8(1):158-61 - PubMed
  42. Aliment Pharmacol Ther. 2003 Jun 15;17(12):1465-70 - PubMed

Publication Types