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Jin J, Zhang XY, Shi JL, et al. Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong. Am J Cancer Res. 2017;7(6):1384-1388
Jin, J., Zhang, X. Y., Shi, J. L., Xue, X. F., Lu, L. L., Lu, J. H., Jiang, X. P., Hu, J. F., Duan, B. S., Yang, C. Q., Lu, D. R., Lu, D. L., Chen, J. G., & Gao, H. J. (2017). Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong. American journal of cancer research, 7(6), 1384-1388.
Jin, Jie, et al. "Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong." American journal of cancer research vol. 7,6 (2017): 1384-1388.
Jin J, Zhang XY, Shi JL, Xue XF, Lu LL, Lu JH, Jiang XP, Hu JF, Duan BS, Yang CQ, Lu DR, Lu DL, Chen JG, Gao HJ. Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong. Am J Cancer Res. 2017 Jun 01;7(6):1384-1388. eCollection 2017. PMID: 28670498; PMCID: PMC5489785.
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Am J Cancer Res. 2017 Jun 01;7(6):1384-1388. eCollection 2017.

Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong.

American journal of cancer research

Jie Jin, Xiao-Yan Zhang, Jin-Lei Shi, Xue-Feng Xue, Ling-Ling Lu, Jian-Hua Lu, Xiao-Ping Jiang, Jiang-Feng Hu, Ben-Song Duan, Chang-Qing Yang, Da-Ru Lu, De-Li Lu, Jian-Guo Chen, Heng-Jun Gao

Affiliations

  1. National Engineering Center for Biochip at ShanghaiShanghai 201203, China.
  2. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan UniversityShanghai, China.
  3. Qidong Liver Cancer Institute226200, Jiangsu, China.
  4. Tongji Institute of Digestive Disease & Department of Gastroenterology, Tongji UniversityShanghai, China.
  5. Department of Bioengineering, University of Illinois at ChicagoChicago, USA.

PMID: 28670498 PMCID: PMC5489785

Abstract

Hepatocellular carcinoma (HCC) is a big problem in China where the Hepatitis B (HBV) infection patients are near to 120 million. Early screening and diagnosis is the key to reduce the incidence and mortality of HCC. Serum AFP detection is the main methods for diagnosis, recurrent monitoring and therapeutic evaluation of primary HCC. Hepatitis patients should detect the AFP at least once every six months to help early diagnosis of HCC. Unfortunately, most hepatitis and other liver disease patients do not test their AFP regularly. Therefore, a rapid, convenient detect kit for AFP is necessary for the hepatitis patients to test AFP at home by themselves. It will be very helpful to the HCC early screening and early diagnosis. We screened 859 individuals who were HBsAg positive and had high risk of HCC in Qidong by using two different kits, AFP one-step rapid detection kit (Shanghai Outdo Biotech) and AFP Diagnostics ELISA kit (Zhengzhou Autobio Diagnostics), and compared the results. As a result, the positive accordance rate and the negative accordance rate of AFP one-step rapid detection kit and the Autobio ELISA kit were 95.65% (22/23) and 99.40% (831/836), respectively. The total diagnose accordance rate reached up to 99.30% (853/859). The screening results showed a high accordance rate of two methods. It is so meaningful to achieve home-test and improve HCC early screening and diagnosis by using AFP one-step rapid detection kit.

Keywords: AFP; HCC; accordance rate; early diagnosis; whole blood one-step rapid detection

Conflict of interest statement

None.

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