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Roos A, Ding Z, Loftus JC, et al. Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion. Front Oncol. 2017;7:120doi: 10.3389/fonc.2017.00120.
Roos, A., Ding, Z., Loftus, J. C., & Tran, N. L. (2017). Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion. Frontiers in oncology, 7120. https://doi.org/10.3389/fonc.2017.00120
Roos, Alison, et al. "Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion." Frontiers in oncology vol. 7 (2017): 120. doi: https://doi.org/10.3389/fonc.2017.00120
Roos A, Ding Z, Loftus JC, Tran NL. Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion. Front Oncol. 2017 Jun 16;7:120. doi: 10.3389/fonc.2017.00120. eCollection 2017. PMID: 28670569; PMCID: PMC5472661.
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Front Oncol. 2017 Jun 16;7:120. doi: 10.3389/fonc.2017.00120. eCollection 2017.

Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion.

Frontiers in oncology

Alison Roos, Zonghui Ding, Joseph C Loftus, Nhan L Tran

Affiliations

  1. Departments of Cancer Biology and Neurosurgery, Mayo Clinic Arizona, Scottsdale, AZ, United States.
  2. Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, United States.

PMID: 28670569 PMCID: PMC5472661 DOI: 10.3389/fonc.2017.00120

Abstract

Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults with a 5-year survival rate of 5% despite intensive research efforts. The poor prognosis is due, in part, to aggressive invasion into the surrounding brain parenchyma. Invasion is a complex process mediated by cell-intrinsic pathways, extrinsic microenvironmental cues, and biophysical cues from the peritumoral stromal matrix. Recent data have attributed GBM invasion to the glioma stem-like cell (GSC) subpopulation. GSCs are slowly dividing, highly invasive, therapy resistant, and are considered to give rise to tumor recurrence. GSCs are localized in a heterogeneous cellular niche, and cross talk between stromal cells and GSCs cultivates a fertile environment that promotes GSC invasion. Pro-migratory soluble factors from endothelial cells, astrocytes, macrophages, microglia, and non-stem-like tumor cells can stimulate peritumoral invasion of GSCs. Therefore, therapeutic efforts designed to target the invasive GSCs may enhance patient survival. In this review, we summarize the current understanding of extrinsic pathways and major stromal and immune players facilitating GSC maintenance and survival.

Keywords: glioblastoma; glioma stem-like cells; invasion; stem-cell niches; survival

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