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Tsujii Y, Hayashi Y, Kawai N, et al. Risk of perforation in balloon dilation associated with steroid injection for preventing esophageal stricture after endoscopic submucosal dissection. Endosc Int Open. 2017;5(7):E573-E579doi: 10.1055/s-0043-110077.
Tsujii, Y., Hayashi, Y., Kawai, N., Yamada, T., Yamamoto, K., Hayashi, S., Yoshii, S., Nagai, K., Inoue, T., Nishida, T., Iijima, H., Mita, E., Inoue, A., & Takehara, T. (2017). Risk of perforation in balloon dilation associated with steroid injection for preventing esophageal stricture after endoscopic submucosal dissection. Endoscopy international open, 5(7), E573-E579. https://doi.org/10.1055/s-0043-110077
Tsujii, Yoshiki, et al. "Risk of perforation in balloon dilation associated with steroid injection for preventing esophageal stricture after endoscopic submucosal dissection." Endoscopy international open vol. 5,7 (2017): E573-E579. doi: https://doi.org/10.1055/s-0043-110077
Tsujii Y, Hayashi Y, Kawai N, Yamada T, Yamamoto K, Hayashi S, Yoshii S, Nagai K, Inoue T, Nishida T, Iijima H, Mita E, Inoue A, Takehara T. Risk of perforation in balloon dilation associated with steroid injection for preventing esophageal stricture after endoscopic submucosal dissection. Endosc Int Open. 2017 Jul;5(7):E573-E579. doi: 10.1055/s-0043-110077. Epub 2017 Jun 23. PMID: 28670613; PMCID: PMC5482748.
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Endosc Int Open. 2017 Jul;5(7):E573-E579. doi: 10.1055/s-0043-110077. Epub 2017 Jun 23.

Risk of perforation in balloon dilation associated with steroid injection for preventing esophageal stricture after endoscopic submucosal dissection.

Endoscopy international open

Yoshiki Tsujii, Yoshito Hayashi, Naoki Kawai, Takuya Yamada, Katsumi Yamamoto, Shiro Hayashi, Shunsuke Yoshii, Kengo Nagai, Takuya Inoue, Tsutomu Nishida, Hideki Iijima, Eiji Mita, Atsuo Inoue, Tetsuo Takehara

Affiliations

  1. Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  2. Department of Gastroenterology, Osaka General Medical Center, Osaka, Japan.
  3. Department of Gastroenterology, Osaka National Hospital, National Hospital Organization, Osaka, Japan.
  4. Department of Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, Japan.
  5. Department of Gastroenterology, Osaka Hospital, Japan Community Health Care Organization, Osaka, Japan.

PMID: 28670613 PMCID: PMC5482748 DOI: 10.1055/s-0043-110077

Abstract

BACKGROUND AND STUDY AIMS:  Endoscopic local steroid injection (LSI) has been used to prevent esophageal strictures after endoscopic submucosal dissection (ESD) for superficial esophageal neoplasms (SENs). This study aimed to evaluate the safety and efficacy of LSI therapy.

PATIENTS AND METHODS:  From May 2007 to September 2014, at four institutions, 40 consecutive patients with SENs were treated with ESD that left a mucosal defect of more than three-quarters of the esophageal circumference. Two patients who underwent esophagectomy after ESD were excluded, and 38 patients were analyzed. The incidence of post-ESD strictures and adverse events associated with LSI were retrospectively investigated.

RESULTS:  Prophylactic LSI was administered in 28 patients (LSI group), and not administered in 10 patients (Non-prevention group). Post-ESD stricture rates were significantly lower in the LSI group (43 %) than in the Non-prevention group (90 %) (

CONCLUSION:  LSI is useful for preventing post-ESD strictures, but it appears to increase the risk of perforation in cases of EBD.

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