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Pifl C, Reither H, Del Rey NL, et al. Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys. Front Neuroanat. 2017;11:46doi: 10.3389/fnana.2017.00046.
Pifl, C., Reither, H., Del Rey, N. L., Cavada, C., Obeso, J. A., & Blesa, J. (2017). Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys. Frontiers in neuroanatomy, 1146. https://doi.org/10.3389/fnana.2017.00046
Pifl, Christian, et al. "Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys." Frontiers in neuroanatomy vol. 11 (2017): 46. doi: https://doi.org/10.3389/fnana.2017.00046
Pifl C, Reither H, Del Rey NL, Cavada C, Obeso JA, Blesa J. Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys. Front Neuroanat. 2017 May 29;11:46. doi: 10.3389/fnana.2017.00046. eCollection 2017. PMID: 28611598; PMCID: PMC5447291.
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Front Neuroanat. 2017 May 29;11:46. doi: 10.3389/fnana.2017.00046. eCollection 2017.

Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys.

Frontiers in neuroanatomy

Christian Pifl, Harald Reither, Natalia Lopez-Gonzalez Del Rey, Carmen Cavada, Jose A Obeso, Javier Blesa

Affiliations

  1. Center for Brain Research, Medical University of ViennaVienna, Austria.
  2. HM CINAC, Hospital Universitario HM Puerta del SurMostoles, Spain.
  3. Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Ministerio de Ciencia e InnovacionMadrid, Spain.
  4. Departamento de Anatomia, Histologia y Neurociencia, Facultad de Medicina, Universidad Autonoma de MadridMadrid, Spain.

PMID: 28611598 PMCID: PMC5447291 DOI: 10.3389/fnana.2017.00046

Abstract

Parkinson's disease (PD) is a neurodegenerative disease with both motor and non-motor manifestations. Hyposmia is one of the early non-motor symptoms, which can precede motor symptoms by several years. The relationship between hyposmia and PD remains elusive. Olfactory bulb (OB) pathology shows an increased number of olfactory dopaminergic cells, protein aggregates and dysfunction of neurotransmitter systems. In this study we examined tissue levels of dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) and their metabolites, of noradrenaline (NA) and of the amino acid neurotransmitters aspartate, glutamate, taurine and γ-aminobutyric acid in OBs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated

Keywords: MPTP; amino acid neurotransmitters; dopamine; noradrenaline; olfactory bulb; serotonin

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