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Memic A, Navaei A, Mirani B, et al. Bioprinting technologies for disease modeling. Biotechnol Lett. 2017;39(9):1279-1290doi: 10.1007/s10529-017-2360-z.
Memic, A., Navaei, A., Mirani, B., Cordova, J. A. V., Aldhahri, M., Dolatshahi-Pirouz, A., Akbari, M., & Nikkhah, M. (2017). Bioprinting technologies for disease modeling. Biotechnology letters, 39(9), 1279-1290. https://doi.org/10.1007/s10529-017-2360-z
Memic, Adnan, et al. "Bioprinting technologies for disease modeling." Biotechnology letters vol. 39,9 (2017): 1279-1290. doi: https://doi.org/10.1007/s10529-017-2360-z
Memic A, Navaei A, Mirani B, Cordova JAV, Aldhahri M, Dolatshahi-Pirouz A, Akbari M, Nikkhah M. Bioprinting technologies for disease modeling. Biotechnol Lett. 2017 Sep;39(9):1279-1290. doi: 10.1007/s10529-017-2360-z. Epub 2017 May 26. PMID: 28550360.
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Biotechnol Lett. 2017 Sep;39(9):1279-1290. doi: 10.1007/s10529-017-2360-z. Epub 2017 May 26.

Bioprinting technologies for disease modeling.

Biotechnology letters

Adnan Memic, Ali Navaei, Bahram Mirani, Julio Alvin Vacacela Cordova, Musab Aldhahri, Alireza Dolatshahi-Pirouz, Mohsen Akbari, Mehdi Nikkhah

Affiliations

  1. Center of Nanotechnology, King Abdulaziz University, Jeddah, Saudi Arabia.
  2. Biomaterials Research Innovation Center, Harvard Medical School, Brigham and Women's Hospital, Cambridge, MA, USA.
  3. School of Biological and Health Systems Engineering (SBHSE), Arizona State University, Tempe, AZ, USA.
  4. Center for Biomedical Research, University of Victoria, Victoria, Canada.
  5. Centre for Advanced Materials and Related Technology (CAMTEC), University of Victoria, Victoria, Canada.
  6. Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, 2800, Lyngby, Denmark.
  7. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  8. School of Biological and Health Systems Engineering (SBHSE), Arizona State University, Tempe, AZ, USA. [email protected].

PMID: 28550360 DOI: 10.1007/s10529-017-2360-z

Abstract

There is a great need for the development of biomimetic human tissue models that allow elucidation of the pathophysiological conditions involved in disease initiation and progression. Conventional two-dimensional (2D) in vitro assays and animal models have been unable to fully recapitulate the critical characteristics of human physiology. Alternatively, three-dimensional (3D) tissue models are often developed in a low-throughput manner and lack crucial native-like architecture. The recent emergence of bioprinting technologies has enabled creating 3D tissue models that address the critical challenges of conventional in vitro assays through the development of custom bioinks and patient derived cells coupled with well-defined arrangements of biomaterials. Here, we provide an overview on the technological aspects of 3D bioprinting technique and discuss how the development of bioprinted tissue models have propelled our understanding of diseases' characteristics (i.e. initiation and progression). The future perspectives on the use of bioprinted 3D tissue models for drug discovery application are also highlighted.

Keywords: 3D bioprinting; Disease microenvironment; Disease modeling; In vitro tissue models

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