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Saini PA, Chakrabarti PR, Varma AV, et al. Hepatitis C Virus: Unnoticed and on the Rise in Blood Donor Screening? A 5 Years Cross-sectional Study on Seroprevalence in Voluntary Blood Donors from Central India. J Glob Infect Dis. 2017;9(2):51-55doi: 10.4103/0974-777X.205172.
Saini, P. A., Chakrabarti, P. R., Varma, A. V., Gambhir, S., Tignath, G., & Gupta, P. (2017). Hepatitis C Virus: Unnoticed and on the Rise in Blood Donor Screening? A 5 Years Cross-sectional Study on Seroprevalence in Voluntary Blood Donors from Central India. Journal of global infectious diseases, 9(2), 51-55. https://doi.org/10.4103/0974-777X.205172
Saini, Purti Agrawal, et al. "Hepatitis C Virus: Unnoticed and on the Rise in Blood Donor Screening? A 5 Years Cross-sectional Study on Seroprevalence in Voluntary Blood Donors from Central India." Journal of global infectious diseases vol. 9,2 (2017): 51-55. doi: https://doi.org/10.4103/0974-777X.205172
Saini PA, Chakrabarti PR, Varma AV, Gambhir S, Tignath G, Gupta P. Hepatitis C Virus: Unnoticed and on the Rise in Blood Donor Screening? A 5 Years Cross-sectional Study on Seroprevalence in Voluntary Blood Donors from Central India. J Glob Infect Dis. 2017 Apr-Jun;9(2):51-55. doi: 10.4103/0974-777X.205172. PMID: 28584455; PMCID: PMC5452551.
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J Glob Infect Dis. 2017 Apr-Jun;9(2):51-55. doi: 10.4103/0974-777X.205172.

Hepatitis C Virus: Unnoticed and on the Rise in Blood Donor Screening? A 5 Years Cross-sectional Study on Seroprevalence in Voluntary Blood Donors from Central India.

Journal of global infectious diseases

Purti Agrawal Saini, Preeti Rihal Chakrabarti, Amit V Varma, Shankhini Gambhir, Gargi Tignath, Priyanka Gupta

Affiliations

  1. Department of Pathology, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.

PMID: 28584455 PMCID: PMC5452551 DOI: 10.4103/0974-777X.205172

Abstract

CONTEXT: The ultimate goal of a blood transfusion service is the provision of safe and adequate supply free from transfusion-transmitted infections (TTIs). TTIs not only threaten the recipient's safety, but they also increase disease burden. Seroprevalence of TTIs in healthy blood donors indirectly reflects the prevalence of these infections in the general healthy population.

AIM AND OBJECTIVES: To study the seroprevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) in healthy donors at a tertiary care hospital-based blood bank. To know the yearly and age-group prevalence of these TTIs as compared with other studies across India.

SETTINGS AND DESIGN: This is 5 years observational cross-section study conducted in a tertiary hospital-based teaching institute of Central India (Malwa region).

MATERIALS AND METHODS: The results of serological testing of TTIs and donor variables were analyzed during 2011-2015.

STATISTICAL ANALYSIS USED: Chi-square test and Chi-square for trend analysis on TTIs prevalence.

RESULTS: A total of 58,998 donors were screened for TTIs with dominance of male donation (99.7%). The overall cumulative seroprevalence was 1.14% in our study. The seroprevalence of HIV, HBV, and HCV was 0.09%, 0.98%, and 0.07%, respectively. We found a statistically significant increasing trend for HCV seropositivity during the study.

CONCLUSION: Our study reflects an increasing trend of HCV seroprevalence over time. Thus, efforts are needed to increase the awareness and to educate the population in reducing risk factors for HCV infection.

Keywords: Hepatitis B virus; hepatitis C virus; human immunodeficiency virus; seroprevalence; transfusion transmitted infections

Conflict of interest statement

There are no conflicts of interest.

References

  1. Indian J Hematol Blood Transfus. 2010 Sep;26(3):89-91 - PubMed
  2. Indian J Public Health. 2014 Jan-Mar;58(1):61-4 - PubMed
  3. Indian J Med Res. 2015 Sep;142(3):317-22 - PubMed
  4. J Family Med Prim Care. 2012 Jan;1(1):48-51 - PubMed
  5. Indian J Med Res. 2011 Dec;134(6):950-3 - PubMed
  6. J Tradit Complement Med. 2015 Apr 03;6(3):224-9 - PubMed
  7. Indian J Med Res. 2013;138:125-8 - PubMed
  8. Indian J Pathol Microbiol. 2010 Apr-Jun;53(2):308-9 - PubMed

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